Curated Information
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Home > Curated Information Page > PubMed Id: 15569773
Okoshi Y, et al. (2005) Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol 17, 65-72 15569773
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y262-p - MAIR-I (mouse)
Modsite: SQVEVVEySTLALPQ SwissProt Entrez-Gene
Orthologous residues
MAIR‑I (human): Y255‑p, MAIR‑I (mouse): Y262‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHIP (mouse) Induces co-immunoprecipitation
SHP-2 (mouse) Induces co-immunoprecipitation
SHP-1 (mouse) Induces co-immunoprecipitation

Y274-p - MAIR-I (mouse)
Modsite: LPQEELHySSVAFNS SwissProt Entrez-Gene
Orthologous residues
MAIR‑I (human): Y267‑p, MAIR‑I (mouse): Y274‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHIP (mouse) Induces co-immunoprecipitation
SHP-2 (mouse) Induces co-immunoprecipitation
SHP-1 (mouse) Induces co-immunoprecipitation