Lo HW, Antoun GR, Ali-Osman F (2004) The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Res 64, 9131-8 15604283

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S43-p - GSTP1 (human) ▲

Modsite: VETWQEGsLkAsCLy SwissProt Entrez-Gene Orthologous residues GSTP1 (human): S43‑p, GSTP1 (mouse): L43‑p, GSTP1 (rat): S43‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Disease tissue studied:  brain cancer, glioblastoma, glioma Relevant cell lines - cell types - tissues:  MGR3 (glial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCH (human) Downstream Regulation Effect of modification (function):  activity, induced

S185-p - GSTP1 (human) ▲

Modsite: SAYVGRLsARPkLkA SwissProt Entrez-Gene Orthologous residues GSTP1 (human): S185‑p, GSTP1 (mouse): S185‑p, GSTP1 (rat): S185‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Disease tissue studied:  brain cancer, glioblastoma, glioma Relevant cell lines - cell types - tissues:  MGR3 (glial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow) KINASE PKCA (human) KINASE PKCH (human) Downstream Regulation Effect of modification (function):  activity, induced