Curated Information
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Home > Curated Information Page > PubMed Id: 15611095
Manno S, Takakuwa Y, Mohandas N (2005) Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation. J Biol Chem 280, 7581-7 15611095
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S726-p - ADD1 (human)
Modsite: KKKFRtPsFLKKsKK SwissProt Entrez-Gene
Orthologous residues
ADD1 (human): S726‑p, ADD1 iso2 (human): , ADD1 iso3 (human): S757‑p, ADD1 iso4 (human): , ADD1 (mouse): S724‑p, ADD1 iso2 (mouse): , ADD1 iso3 (mouse): , ADD1 (rat): S724‑p, ADD1 (cow): S758‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  erythrocyte-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCZ (human) pharmacological activator of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester, calyculin_A increase

S713-p - ADD2 (human)
Modsite: KKKFRtPsFLKKsKK SwissProt Entrez-Gene
Orthologous residues
ADD2 (human): S713‑p, ADD2 iso2 (human): , ADD2 (mouse): S712‑p, ADD2 iso2 (mouse): , ADD2 (rat): S712‑p, ADD2 iso2 (rat):
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  erythrocyte-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCZ (human) pharmacological activator of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester, calyculin_A increase

S312-p - EPB41 iso4 (human)
Modsite: QAQTRQAsALIDRPA SwissProt Entrez-Gene
Orthologous residues
EPB41 (human): S521‑p, EPB41 iso2 (human): S521‑p, EPB41 iso4 (human): S312‑p, EPB41 iso5 (human): S486‑p, EPB41 (mouse): S522‑p, EPB41 iso3 (mouse): , EPB41 iso6 (mouse): S245‑p, EPB41 (rat): S520‑p
Characterization
Methods used to characterize site in vivo peptide sequencing, phospho-antibody
Relevant cell lines - cell types - tissues:  erythrocyte-blood
Cellular systems studied:  primary cells
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) pharmacological activator of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester, calyculin_A increase