Mukherjee S, et al. (2006) Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312, 1211-4 16728640

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S207-ac - MKK6 (human) ▲

Modsite: IsGyLVDsVAKtIDA SwissProt Entrez-Gene Orthologous residues MKK6 (human): S207‑ac, MKK6 iso2 (human): S151‑ac, MKK6 (mouse): S207‑ac, MKK6 (rat): S207‑ac Characterization Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE yopJ (bacteria) Downstream Regulation Effect of modification (function):  enzymatic activity, inhibited, phosphorylation Comments:  yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro

T211-ac - MKK6 (human) ▲

Modsite: LVDsVAKtIDAGCKP SwissProt Entrez-Gene Orthologous residues MKK6 (human): T211‑ac, MKK6 iso2 (human): T155‑ac, MKK6 (mouse): T211‑ac, MKK6 (rat): T211‑ac Characterization Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE yopJ (bacteria) Downstream Regulation Effect of modification (function):  enzymatic activity, inhibited, phosphorylation Comments:  yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro