Qin J, et al. (2008) Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway. Cancer Res 68, 4150-62 18519674

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S18-p - p53 (mouse) ▲

Modsite: IsLELPLsQEtFsGL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  lung cancer, non-small cell lung cancer Relevant cell lines - cell types - tissues:  JB6 CI41 (epidermal), NCI-H1299 (pulmonary) Cellular systems studied:  cell lines Species studied:  human, mouse Enzymes shown to modify site in vitro:  Type Enzyme PHOSPHATASE PPP2CA (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes PHOSPHATASE PPP2CA (mouse) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes phorbol_ester no change compared to control EGCG phorbol_ester increase EGCG PPP2CA (mouse) inhibit treatment-induced increase okadaic_acid, EGCG phorbol_ester increase adriamycin increase Downstream Regulation Effect of modification (process):  apoptosis, induced

S23-p - p53 (mouse) ▲

Modsite: PLsQEtFsGLWKLLP SwissProt Entrez-Gene Orthologous residues p53 (human): S20‑p, p53 iso2 (human): S20‑p, p53 iso4 (human): ‑, p53 (mouse): S23‑p, p53 iso2 (mouse): S23‑p, p53 (rat): S20‑p, p53 (rabbit): S20‑p, p53 (green monkey): S20‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes adriamycin increase