Curated Information
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Home > Curated Information Page > PubMed Id: 18559482
Minella AC, et al. (2008) Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev 22, 1677-89 18559482
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T74-p - CCNE1 (mouse)
Modsite: DPCSFIPtPNKEEDN SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T77‑p, CCNE1 (mouse): T74‑p, CCNE1 (rat): T77‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast)
Cellular systems studied:  primary cells, primary cultured cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  activity, inhibited, protein degradation
Effect of modification (process):  cell cycle regulation, cell differentiation, altered, cell growth, altered
Comments:  T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7.

T393-p - CCNE1 (mouse)
Modsite: PPPsVVLtPPPSSKK SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T395‑p, CCNE1 (mouse): T393‑p, CCNE1 (rat): T396‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast)
Cellular systems studied:  primary cells, primary cultured cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  activity, inhibited, protein degradation
Effect of modification (process):  cell cycle regulation, cell differentiation, altered, cell growth, altered
Comments:  T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7.