Ohrt T, Mancini A, Tamura T, Niedenthal R (2004) c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination. Cell Signal 16, 1291-8 15337528

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Y337-p - NGFR (rat) ▲

Modsite: LKGDGNLySSLPLTK SwissProt Entrez-Gene Orthologous residues NGFR (human): Y336‑p, NGFR (mouse): Y339‑p, NGFR (rat): Y337‑p, NGFR (chicken): Y325‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody Relevant cell lines - cell types - tissues:  293 (epithelial), PCNA Cellular systems studied:  cell lines, tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes vanadate increase Downstream Regulation Effect of modification (function):  molecular association, regulation, protein degradation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CBL (mouse) Induces co-immunoprecipitation, in vitro, yeast two-hybrid