Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 15545601
Aiba Y, et al. (2004) Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A 101, 16612-7 15545601
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.

T133-p - RASGRP3 (chicken)
Modsite: YDWMRRVtQRKKISK SwissProt Entrez-Gene
Orthologous residues
RASGRP3 (human): T133‑p, RASGRP3 iso2 (human): T133‑p, RASGRP3 (mouse): T133‑p, RASGRP3 (rat): T133‑p, RASGRP3 (chicken): T133‑p
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte), HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  chicken, human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) genetic knockout/knockin of upstream enzyme, mutation in upstream enzyme recognition motif, pharmacological inhibitor of upstream enzyme, co-immunoprecipitation, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  activity, induced