Aiba Y, et al. (2004) Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A 101, 16612-7 15545601

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

T133-p - RASGRP3 (chicken) ▲

Modsite: YDWMRRVtQRKKISK SwissProt Entrez-Gene Orthologous residues RASGRP3 (human): T133‑p, RASGRP3 iso2 (human): T133‑p, RASGRP3 (mouse): T133‑p, RASGRP3 (rat): T133‑p, RASGRP3 (chicken): T133‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte), HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  chicken, human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCB (human) genetic knockout/knockin of upstream enzyme, mutation in upstream enzyme recognition motif, pharmacological inhibitor of upstream enzyme, co-immunoprecipitation, transfection of wild-type enzyme Downstream Regulation Effect of modification (function):  activity, induced