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Home > Curated Information Page > PubMed Id: 17998938
Colomba A, et al. (2008) Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas. Oncogene 27, 2728-36 17998938
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y343-p - NPM-ALK (human)
Modsite: DIyRAsyyRKGGCAM GenPept
Orthologous residues
NPM‑ALK (human): Y343‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
VAV3 (human) SH2 Induces co-immunoprecipitation

Y664-p - NPM-ALK (human)
Modsite: TAPGAGHyEDTILKS GenPept
Orthologous residues
NPM‑ALK (human): Y664‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
WHI-P154 decrease
LY294002 no change compared to control
SU6656 decrease

Y173-p - VAV3 (human)
Modsite: EDEGGEVyEDLMKAE SwissProt Entrez-Gene
Orthologous residues
VAV3 (human): Y173‑p, VAV3 iso4 (human): Y173‑p, VAV3 (mouse): Y173‑p, VAV3 (rat): Y173‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) phospho-antibody, pharmacological inhibitor of upstream enzyme, siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
WHI-P154 decrease
SU6656 decrease

S199-p - PAK1 (mouse)
Modsite: PRPEHTKsVYTRsVI SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): S199‑p, PAK1 (mouse): S199‑p, PAK1 (rat): S198‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NPM-ALK (human) increase
LY294002 NPM-ALK (human) inhibit treatment-induced increase
SU6656 NPM-ALK (human) inhibit treatment-induced increase

S204-p - PAK1 (mouse)
Modsite: TKsVYTRsVIEPLPV SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): S204‑p, PAK1 (mouse): S204‑p, PAK1 (rat): S203‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NPM-ALK (human) increase
LY294002 NPM-ALK (human) inhibit treatment-induced increase
SU6656 NPM-ALK (human) inhibit treatment-induced increase

S192-p - PAK2 (mouse)
Modsite: PRPDHTKsIYtRsVI SwissProt Entrez-Gene
Orthologous residues
PAK2 (human): S192‑p, PAK2 (mouse): S192‑p, PAK2 (rat): S192‑p, PAK2 (rabbit): S192‑p, PAK2 (cow): S192‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NPM-ALK (human) increase
LY294002 NPM-ALK (human) inhibit treatment-induced increase
SU6656 NPM-ALK (human) inhibit treatment-induced increase

S197-p - PAK2 (mouse)
Modsite: TKsIYtRsVIDPIPA SwissProt Entrez-Gene
Orthologous residues
PAK2 (human): S197‑p, PAK2 (mouse): S197‑p, PAK2 (rat): S197‑p, PAK2 (rabbit): S197‑p, PAK2 (cow): S197‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NPM-ALK (human) increase
LY294002 NPM-ALK (human) inhibit treatment-induced increase
SU6656 NPM-ALK (human) inhibit treatment-induced increase

Y173-p - VAV3 (mouse)
Modsite: EDEGGEVyEDLMKAE SwissProt Entrez-Gene
Orthologous residues
VAV3 (human): Y173‑p, VAV3 iso4 (human): Y173‑p, VAV3 (mouse): Y173‑p, VAV3 (rat): Y173‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NPM-ALK (human) increase