Curated Information
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Home > Curated Information Page > PubMed Id: 26258553
An C, et al. (2015) Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension. PLoS One 10, e0134876 26258553
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S19-p - MRLC2V (mouse)
Modsite: GGssNVFsMFEQtQI SwissProt Entrez-Gene
Orthologous residues
MRLC2V (human): S19‑p, MRLC2V (mouse): S19‑p, MRLC2V (rat): S19‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  stomach
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  gastric fundus smooth muscles
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl increase
carbachol increase
electrical_stimulation no change compared to control

T694-p - MYPT1 (mouse)
Modsite: ARQSRRstQGVTLTD SwissProt Entrez-Gene
Orthologous residues
MYPT1 (human): T696‑p, MYPT1 iso2 (human): T696‑p, MYPT1 iso3 (human): T640‑p, MYPT1 iso4 (human): T637‑p, MYPT1 (mouse): T694‑p, MYPT1 (rat): T697‑p, MYPT1 (pig): T696‑p, MYPT1 (chicken): T695‑p, MYPT1 (cow): T696‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  stomach
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  gastric fundus smooth muscles
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl no change compared to control
carbachol increase
electrical_stimulation no change compared to control

T852-p - MYPT1 (mouse)
Modsite: PREKRRstGVSFWtQ SwissProt Entrez-Gene
Orthologous residues
MYPT1 (human): T853‑p, MYPT1 iso2 (human): T853‑p, MYPT1 iso3 (human): T797‑p, MYPT1 iso4 (human): T794‑p, MYPT1 (mouse): T852‑p, MYPT1 (rat): T855‑p, MYPT1 (pig): , MYPT1 (chicken): T850‑p, MYPT1 (cow): T851‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  stomach
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  gastric fundus smooth muscles
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl no change compared to control
carbachol increase
electrical_stimulation no change compared to control

T38-p - PPP1R14A (mouse)
Modsite: QKRHARVtVKYDRRE SwissProt Entrez-Gene
Orthologous residues
PPP1R14A (human): T38‑p, PPP1R14A iso2 (human): T38‑p, PPP1R14A (mouse): T38‑p, PPP1R14A (rat): T38‑p, PPP1R14A (pig): T38‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  stomach
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  gastric fundus smooth muscles
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
KCl increase
carbachol increase
electrical_stimulation no change compared to control

S13-p - smMLCK (mouse)
Modsite: LFASSHMsKTSHSVD SwissProt Entrez-Gene
Orthologous residues
smMLCK (human): S13‑p, smMLCK iso2 (human): S13‑p, smMLCK iso6 (human): S13‑p, smMLCK (mouse): S13‑p, smMLCK (rat): S22‑p, smMLCK (rabbit): , smMLCK (chicken): S13‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  stomach
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  gastric fundus smooth muscles
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cGMP_analog increase
SNP increase
ODQ no change compared to control
KCl no change compared to control
carbachol no change compared to control
electrical_stimulation no change compared to control