Curated Information
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Home > Curated Information Page > PubMed Id: 26248194
Zhao M, Gjerset RA (2015) Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. PLoS One 10, e0134929 26248194
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S506-p - TOP1 (human)
Modsite: ADTVGCCsLRVEHIN SwissProt Entrez-Gene
Orthologous residues
TOP1 (human): S506‑p, TOP1 (mouse): S508‑p, TOP1 (rat): S508‑p, TOP1 (cow): S510‑p
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma, lung cancer, non-small cell lung cancer, ovarian cancer
Relevant cell lines - cell types - tissues:  COLO-205 (intestinal), lung, NCI-H358 (pulmonary), OVCAR3 (ovarian)
Cellular systems studied:  cell lines, tissue
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
camptothecin decrease
Associated Diseases
Diseases Alterations Comments
ovarian cancer, colorectal carcinoma, non-small cell lung adenocarcinoma, surrounding tissue increased