Nadeau MÈ, et al. (2015) Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer 15, 479 26104798

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S139-p - H2AX (human) ▲

Modsite: GkkAtQAsQEy____ SwissProt Entrez-Gene Orthologous residues H2AX (human): S139‑p, H2AX (mouse): S139‑p, H2AX (rat): S139‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  lung cancer, lymphoma Relevant cell lines - cell types - tissues:  CLBL-1 Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes eeyarestatin_1 increase

S15-p - p53 (human) ▲

Modsite: PsVEPPLsQEtFsDL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  lung cancer, lymphoma Relevant cell lines - cell types - tissues:  CLBL-1 Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes eeyarestatin_1 increase Downstream Regulation Effect of modification (process):  transcription, induced Comments:  p21Cip1 mRNA expression