Curated Information
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Home > Curated Information Page > PubMed Id: 26181363
Morgan JE, et al. (2015) The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination. Biosci Rep 35 26181363
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S280-p - CIITA (human)
Modsite: TVHGLPTsPDRPGsT SwissProt Entrez-Gene
Orthologous residues
CIITA (human): S280‑p, CIITA (mouse): S306‑p
Characterization
Methods used to characterize site in vivo flow cytometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK1 (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme
KINASE ERK2 (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  intracellular localization, protein stabilization, ubiquitination
Effect of modification (process):  transcription, induced
Comments:  MHC II transcription, global ubiquitination levels, CIITA nuclear mobilization