Curated Information
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Home > Curated Information Page > PubMed Id: 15277518
Xu NJ, et al. (2004) Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation. J Biol Chem 279, 40601-8 15277518
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S187-p - SNAP-25 (mouse)
Modsite: RIMEkADsNkTRIDE SwissProt Entrez-Gene
Orthologous residues
SNAP‑25 (human): S187‑p, SNAP‑25 iso2 (human): S187‑p, SNAP‑25 (mouse): S187‑p, SNAP‑25 (rat): S187‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (mouse) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
morphine decrease
naloxone morphine augment treatment-induced decrease

S187-p - SNAP-25 (rat)
Modsite: RIMEkADsNkTRIDE SwissProt Entrez-Gene
Orthologous residues
SNAP‑25 (human): S187‑p, SNAP‑25 iso2 (human): S187‑p, SNAP‑25 (mouse): S187‑p, SNAP‑25 (rat): S187‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
morphine decrease