Curated Information
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Home > Curated Information Page > PubMed Id: 26192746
Plattner F, et al. (2015) The role of ventral striatal cAMP signaling in stress-induced behaviors. Nat Neurosci 18, 1094-100 26192746
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S119-p - CREB (mouse)
Modsite: EILSRRPsYRKILND SwissProt Entrez-Gene
Orthologous residues
CREB (human): S119‑p, CREB iso1 (human): S133‑p, CREB (mouse): S119‑p, CREB iso1 (mouse): S133‑p, CREB (rat): S133‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
seliciclib increase

T34-p - DARPP-32 (mouse)
Modsite: MIRRRRPtPAMLFRV SwissProt Entrez-Gene
Orthologous residues
DARPP‑32 (human): T34‑p, DARPP‑32 iso2 (human): , DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5 (mouse) decrease Cdk5 KO increase

T75-p - DARPP-32 (mouse)
Modsite: RPNPCAYtPPSLKAV SwissProt Entrez-Gene
Orthologous residues
DARPP‑32 (human): T75‑p, DARPP‑32 iso2 (human): T39‑p, DARPP‑32 (mouse): T75‑p, DARPP‑32 (rat): T75‑p, DARPP‑32 (cow): T75‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5 (mouse) decrease Cdk5 KO increase

S863-p - GluR1 (mouse)
Modsite: TSTLPRNsGAGASGG SwissProt Entrez-Gene
Orthologous residues
GluR1 (human): S863‑p, GluR1 iso6 (human): S873‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5 (mouse) decrease Cdk5 KO increase

S118-p - PDE4B (mouse)
Modsite: GHSQRREsFLYRSDS SwissProt Entrez-Gene
Orthologous residues
PDE4B (human): S133‑p, PDE4B iso2 (human): , PDE4B iso3 (human): S118‑p, PDE4B (mouse): S118‑p, PDE4B (rat): S133‑p, PDE4B iso1 (rat): S118‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5 (mouse) increase Cdk5 KO inhibits
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S130-p - PDE4B (mouse)
Modsite: SDSDYDLsPKAMSRN SwissProt Entrez-Gene
Orthologous residues
PDE4B (human): S145‑p, PDE4B iso2 (human): , PDE4B iso3 (human): S130‑p, PDE4B (mouse): S130‑p, PDE4B (rat): S145‑p, PDE4B iso1 (rat): S130‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, striatum'
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5 (mouse) increase Cdk5 KO inhibits
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S9-p - SYN1 (mouse)
Modsite: NYLRRRLsDSNFMAN SwissProt Entrez-Gene
Orthologous residues
SYN1 (human): S9‑p, SYN1 iso2 (human): S9‑p, SYN1 (mouse): S9‑p, SYN1 iso1 (mouse): S9‑p, SYN1 iso3 (mouse): S9‑p, SYN1 (rat): S9‑p, SYN1 (cow): S9‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
seliciclib increase