Li Y, et al. (2015) Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis. Oncotarget 6, 24261-76 26155943

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T48-p - Nur77 (human) ▲

Modsite: EAAPAAPtALPsFst SwissProt Entrez-Gene Orthologous residues Nur77 (human): T48‑p, Nur77 iso2 (human): T61‑p, Nur77 (mouse): A48‑p, Nur77 (rat): A48‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers.

S52-p - Nur77 (human) ▲

Modsite: AAPtALPsFstFMDG SwissProt Entrez-Gene Orthologous residues Nur77 (human): S52‑p, Nur77 iso2 (human): S65‑p, Nur77 (mouse): S52‑p, Nur77 (rat): S52‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers.

S54-p - Nur77 (human) ▲

Modsite: PtALPsFstFMDGyt SwissProt Entrez-Gene Orthologous residues Nur77 (human): S54‑p, Nur77 iso2 (human): S67‑p, Nur77 (mouse): S54‑p, Nur77 (rat): S54‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers.

T55-p - Nur77 (human) ▲

Modsite: tALPsFstFMDGytG SwissProt Entrez-Gene Orthologous residues Nur77 (human): T55‑p, Nur77 iso2 (human): T68‑p, Nur77 (mouse): T55‑p, Nur77 (rat): T55‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers.

Y60-p - Nur77 (human) ▲

Modsite: FstFMDGytGEFDTF SwissProt Entrez-Gene Orthologous residues Nur77 (human): Y60‑p, Nur77 iso2 (human): Y73‑p, Nur77 (mouse): Y60‑p, Nur77 (rat): Y61‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers.

T61-p - Nur77 (human) ▲

Modsite: stFMDGytGEFDTFL SwissProt Entrez-Gene Orthologous residues Nur77 (human): T61‑p, Nur77 iso2 (human): T74‑p, Nur77 (mouse): T61‑p, Nur77 (rat): T62‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers.

S351-p - Nur77 (human) ▲

Modsite: GRRGRLPsKPKQPPD SwissProt Entrez-Gene Orthologous residues Nur77 (human): S351‑p, Nur77 iso2 (human): S364‑p, Nur77 (mouse): S354‑p, Nur77 (rat): S350‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HUVEC (endothelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  cell growth, induced, cell motility, induced, cytoskeletal reorganization Comments:  dephosphorylation of S351 is required for increase cell growth, cell motility, monolayer permeability and formation of actin stress fibers.