Yin N, et al. (2016) p38γ MAPK is required for inflammation-associated colon tumorigenesis. Oncogene 35, 1039-48 25961922

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S191-p - CTNNB1 (human) ▲

Modsite: sRHAIMRsPQMVsAI SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S191‑p, CTNNB1 (mouse): S191‑p, CTNNB1 (rat): S191‑p, CTNNB1 (rabbit): S191‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human

S246-p - CTNNB1 (human) ▲

Modsite: ALVKMLGsPVDSVLF SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S246‑p, CTNNB1 (mouse): S246‑p, CTNNB1 (rat): S246‑p, CTNNB1 (rabbit): S246‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human

S605-p - CTNNB1 (human) ▲

Modsite: LFVQLLYsPIENIQR SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S605‑p, CTNNB1 (mouse): S605‑p, CTNNB1 (rat): S605‑p, CTNNB1 (rabbit): S605‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE P38G (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE P38G (human) co-immunoprecipitation, transfection of constitutively active enzyme, phospho-antibody Downstream Regulation Effect of modification (function):  protein stabilization Effect of modification (process):  cell growth, induced, transcription, induced