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Home > Curated Information Page > Cst Curation Set #15872
Rikova K (2012) CST Curation Set: 15872; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST](PSD)
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S187-p - AKAP10 (human)
Modsite: SSLAEPVsPsKKHET SwissProt Entrez-Gene
Orthologous residues
AKAP10 (human): S187‑p, AKAP10 (mouse): S187‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S152-p - AKAP2 (human)
Modsite: DsLQVPVsPssTtss SwissProt Entrez-Gene
Orthologous residues
AKAP2 (human): S152‑p, AKAP2 iso4 (human): S383‑p, AKAP2 iso6 (human): S383‑p, AKAP2 (mouse): S152‑p, AKAP2 iso2 (mouse): S152‑p, AKAP2 iso3 (mouse): S152‑p, AKAP2 iso6 (mouse): S193‑p, AKAP2 (rat): S152‑p, AKAP2 (cow): S152‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1029-p - ARHGAP29 (human)
Modsite: VDRLLLAsPPNERNG SwissProt Entrez-Gene
Orthologous residues
ARHGAP29 (human): S1029‑p, ARHGAP29 (mouse): S1039‑p, ARHGAP29 (rat): G1034‑p, ARHGAP29 (cow): S1037‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1609-p - ARID1A (human)
Modsite: sKsPFLHsGMkMQKA SwissProt Entrez-Gene
Orthologous residues
ARID1A (human): S1609‑p, ARID1A iso2 (human): S1392‑p, ARID1A (mouse): S1610‑p, ARID1A (rat): S1617‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T848-p - CASKIN2 (human)
Modsite: tsPSVtPtPArGtPR SwissProt Entrez-Gene
Orthologous residues
CASKIN2 (human): T848‑p, CASKIN2 iso2 (human): T766‑p, CASKIN2 (mouse): T847‑p, CASKIN2 (rat): T847‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S494-p - CCDC132 (human)
Modsite: KFMEQsRsPsVsPsk SwissProt Entrez-Gene
Orthologous residues
CCDC132 (human): S494‑p, CCDC132 iso3 (human): S464‑p, CCDC132 (mouse): S494‑p, CCDC132 (rat): S54‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T2050-p - CHD-8 (human)
Modsite: MrVsPsDttPLVsRS SwissProt Entrez-Gene
Orthologous residues
CHD‑8 (human): T2050‑p, CHD‑8 iso2 (human): T1771‑p, CHD‑8 (mouse): T2052‑p, CHD‑8 iso2 (mouse): , CHD‑8 (rat): T2050‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S74-p - CRK (human)
Modsite: PRPPVPPsPAQPPPG SwissProt Entrez-Gene
Orthologous residues
CRK (human): S74‑p, CRK iso2 (human): S74‑p, CRK (mouse): S74‑p, CRK iso3 (mouse): S74‑p, CRK (rat): S74‑p, CRK (chicken): G77‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S894-p - DOCK7 (human)
Modsite: AsLNLNRsRsLsNsN SwissProt Entrez-Gene
Orthologous residues
DOCK7 (human): S894‑p, DOCK7 iso2 (human): S894‑p, DOCK7 iso3 (human): S894‑p, DOCK7 (mouse): S894‑p, DOCK7 iso3 (mouse): S894‑p, DOCK7 (rat): S902‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1900-p - ELYS (human)
Modsite: VSTVTsPsRMIRKLR SwissProt Entrez-Gene
Orthologous residues
ELYS (human): S1900‑p, ELYS iso2 (human): S1935‑p, ELYS (mouse): D1886‑p, ELYS (rat): G1884‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T10-p - GGCX (human)
Modsite: VSAGsARtsPSSDkV SwissProt Entrez-Gene
Orthologous residues
GGCX (human): T10‑p, GGCX (mouse): V10‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S243-p - GTSE1 (human)
Modsite: PKKEIPAsPsRTKIP SwissProt Entrez-Gene
Orthologous residues
GTSE1 (human): S243‑p, GTSE1 (mouse): S245‑p, GTSE1 (rat): S254‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S246-p - HDAC4 (human)
Modsite: FPLRkTAsEPNLKLR SwissProt Entrez-Gene
Orthologous residues
HDAC4 (human): S246‑p, HDAC4 (mouse): S245‑p, HDAC4 (rat): S245‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S259-p - HDAC5 (human)
Modsite: FPLRkTAsEPNLKVR SwissProt Entrez-Gene
Orthologous residues
HDAC5 (human): S259‑p, HDAC5 iso2 (human): S259‑p, HDAC5 iso3 (human): S260‑p, HDAC5 (mouse): S250‑p, HDAC5 (rat): S83‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1108-p - HDAC5 (human)
Modsite: AAAAREHsPRPAEEP SwissProt Entrez-Gene
Orthologous residues
HDAC5 (human): S1108‑p, HDAC5 iso2 (human): S1023‑p, HDAC5 iso3 (human): S1109‑p, HDAC5 (mouse): S1099‑p, HDAC5 (rat): S932‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S155-p - HDAC7 (human)
Modsite: FPLRKtVsEPNLkLR SwissProt Entrez-Gene
Orthologous residues
HDAC7 (human): S155‑p, HDAC7 iso3 (human): S155‑p, HDAC7 iso5 (human): S194‑p, HDAC7 iso7 (human): S194‑p, HDAC7 iso8 (human): S211‑p, HDAC7 (mouse): S178‑p, HDAC7 (rat): S156‑p, HDAC7 (cow): S196‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S220-p - HDAC9 (human)
Modsite: FPLRkTAsEPNLKVR SwissProt Entrez-Gene
Orthologous residues
HDAC9 (human): S220‑p, HDAC9 iso3 (human): S220‑p, HDAC9 iso5 (human): S220‑p, HDAC9 iso6 (human): , HDAC9 (mouse): S220‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

Y1044-p - IARS (human)
Modsite: IKAPLkPyPVsPsDk SwissProt Entrez-Gene
Orthologous residues
IARS (human): Y1044‑p, IARS (mouse): Y1044‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1047-p - IARS (human)
Modsite: PLkPyPVsPsDkVLI SwissProt Entrez-Gene
Orthologous residues
IARS (human): S1047‑p, IARS (mouse): P1047‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S971-p - KIAA1522 (human)
Modsite: PPVARKPsVGVPPPA SwissProt Entrez-Gene
Orthologous residues
KIAA1522 (human): S971‑p, KIAA1522 iso2 (human): S1030‑p, KIAA1522 (mouse): S952‑p, KIAA1522 iso2 (mouse): S1009‑p, KIAA1522 (rat): S956‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S979-p - KIAA1522 (human)
Modsite: VGVPPPAsPsyPRAE SwissProt Entrez-Gene
Orthologous residues
KIAA1522 (human): S979‑p, KIAA1522 iso2 (human): S1038‑p, KIAA1522 (mouse): S959‑p, KIAA1522 iso2 (mouse): S1016‑p, KIAA1522 (rat): S962‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

Y37-p - KNOP1 (human)
Modsite: SVLNNDDyFADVsPL SwissProt Entrez-Gene
Orthologous residues
KNOP1 (human): Y37‑p, KNOP1 (mouse): Y46‑p, TSG118 iso2 (mouse): Y46‑p, KNOP1 (rat): Y97‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S601-p - L3MBTL3 (human)
Modsite: RIFPDRLsGEMPPAs SwissProt Entrez-Gene
Orthologous residues
L3MBTL3 (human): S601‑p, L3MBTL3 iso2 (human): S576‑p, L3MBTL3 (mouse): S601‑p, L3MBTL3 (rat): S600‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S608-p - L3MBTL3 (human)
Modsite: sGEMPPAsPsFPRNK SwissProt Entrez-Gene
Orthologous residues
L3MBTL3 (human): S608‑p, L3MBTL3 iso2 (human): S583‑p, L3MBTL3 (mouse): T609‑p, L3MBTL3 (rat): S607‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S540-p - liprin beta 1 (human)
Modsite: KSNKRtAsAPNLAEt SwissProt Entrez-Gene
Orthologous residues
liprin beta 1 (human): S540‑p, liprin beta 1 iso2 (human): S523‑p, liprin beta 1 iso3 (human): S387‑p, liprin beta 1 iso4 (human): S509‑p, liprin beta 1 (mouse): S500‑p, liprin beta 1 iso4 (mouse): S88‑p, liprin beta 1 (rat): S460‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S222-p - MAVS (human)
Modsite: tPSRGPVsPsVSFQP SwissProt Entrez-Gene
Orthologous residues
MAVS (human): S222‑p, MAVS iso4 (human): S81‑p, MAVS (mouse): S220‑p, MAVS (rat): S220‑p, MAVS (cow): S221‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S444-p - MEF2D (human)
Modsite: SIkSEPVsPsRERsP SwissProt Entrez-Gene
Orthologous residues
MEF2D (human): S444‑p, MEF2D iso2 (human): S443‑p, MEF2D iso4 (human): S437‑p, MEF2D (mouse): S437‑p, MEF2D iso2 (mouse): S437‑p, MEF2D (rat): S430‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S446-p - MEF2D (human)
Modsite: kSEPVsPsRERsPAP SwissProt Entrez-Gene
Orthologous residues
MEF2D (human): S446‑p, MEF2D iso2 (human): S445‑p, MEF2D iso4 (human): S439‑p, MEF2D (mouse): S439‑p, MEF2D iso2 (mouse): S439‑p, MEF2D (rat): S432‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S449-p - MGA (human)
Modsite: SSKWLPssPsGVAKA SwissProt Entrez-Gene
Orthologous residues
MGA (human): S449‑p, MGA iso3 (human): S449‑p, MGA iso6 (human): , MGA (mouse): S448‑p, MGA (rat): S447‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S326-p - MIG-6 (human)
Modsite: VPPREPLsPSNsRTP SwissProt Entrez-Gene
Orthologous residues
MIG‑6 (human): S326‑p, MIG‑6 (mouse): S325‑p, MIG‑6 (rat): S324‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S701-p - NAV1 (human)
Modsite: VSSsIDPsLLSTkQG SwissProt Entrez-Gene
Orthologous residues
NAV1 (human): S701‑p, NAV1 iso2 (human): S701‑p, NAV1 iso5 (human): S310‑p, NAV1 (mouse): S703‑p, NAV1 (rat): S703‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S125-p - NPM1 (human)
Modsite: AVEEDAEsEDEEEED SwissProt Entrez-Gene
Orthologous residues
NPM1 (human): S125‑p, NPM1 iso2 (human): S125‑p, NPM1 iso3 (human): S125‑p, NPM1 (mouse): S125‑p, NPM1 (rat): S125‑p, NPM1 iso2 (rat): S125‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S461-p - PHLDB1 (human)
Modsite: MRELPPLsPsLsRRA SwissProt Entrez-Gene
Orthologous residues
PHLDB1 (human): S461‑p, PHLDB1 iso2 (human): S461‑p, PHLDB1 (mouse): S463‑p, PHLDB1 (rat): S462‑p, PHLDB1 (cow): S463‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T714-p - PPFIA3 (human)
Modsite: GPAIPGDtPPPtPRs SwissProt Entrez-Gene
Orthologous residues
PPFIA3 (human): T714‑p, PPFIA3 iso2 (human): T714‑p, PPFIA3 (mouse): T714‑p, PPFIA3 (rat): T712‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1103-p - RAP140 (human)
Modsite: GGNLPPVsPNDsGAK SwissProt Entrez-Gene
Orthologous residues
RAP140 (human): S1103‑p, RAP140 iso2 (human): S666‑p, RAP140 iso3 (human): S1103‑p, RAP140 (mouse): S1059‑p, RAP140 iso2 (mouse): S1089‑p, RAP140 (rat): S1097‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1699-p - RBBP6 (human)
Modsite: sHssPsVsPsRsHsP SwissProt Entrez-Gene
Orthologous residues
RBBP6 (human): S1699‑p, RBBP6 iso2 (human): S1665‑p, RBBP6 (mouse): S1699‑p, RBBP6 iso2 (mouse): S1665‑p, RBBP6 (rat): S1698‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1701-p - RBBP6 (human)
Modsite: ssPsVsPsRsHsPsG SwissProt Entrez-Gene
Orthologous residues
RBBP6 (human): S1701‑p, RBBP6 iso2 (human): S1667‑p, RBBP6 (mouse): S1701‑p, RBBP6 iso2 (mouse): S1667‑p, RBBP6 (rat): S1700‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S479-p - RPRD2 (human)
Modsite: VsPAsRPsPGtPtsP SwissProt Entrez-Gene
Orthologous residues
RPRD2 (human): S479‑p, RPRD2 iso2 (human): S442‑p, RPRD2 iso3 (human): S453‑p, RPRD2 iso5 (human): S453‑p, RPRD2 (mouse): S498‑p, RPRD2 iso2 (mouse): S454‑p, RPRD2 (rat): S369‑p, RPRD2 (cow): S482‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S487-p - RPRD2 (human)
Modsite: PGtPtsPsNLtsGLK SwissProt Entrez-Gene
Orthologous residues
RPRD2 (human): S487‑p, RPRD2 iso2 (human): S450‑p, RPRD2 iso3 (human): S461‑p, RPRD2 iso5 (human): S461‑p, RPRD2 (mouse): S506‑p, RPRD2 iso2 (mouse): S462‑p, RPRD2 (rat): S377‑p, RPRD2 (cow): S490‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S637-p - SATB1 (human)
Modsite: tVAsPAEsDEENRQK SwissProt Entrez-Gene
Orthologous residues
SATB1 (human): S637‑p, SATB1 iso2 (human): S669‑p, SATB1 (mouse): S638‑p, SATB1 (rat): S638‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1066-p - SETDB1 (human)
Modsite: RNYGYNPsPVkPEGL SwissProt Entrez-Gene
Orthologous residues
SETDB1 (human): S1066‑p, SETDB1 iso3 (human): S1066‑p, SETDB1 (mouse): , SETDB1 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T261-p - SF3B1 (human)
Modsite: WDPtPsHtPAGAAtP SwissProt Entrez-Gene
Orthologous residues
SF3B1 (human): T261‑p, SF3B1 (mouse): T261‑p, SF3B1 (rat): T261‑p, SF3B1 (cow): T261‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T278-p - SF3B1 (human)
Modsite: GDtPGHAtPGHGGAt SwissProt Entrez-Gene
Orthologous residues
SF3B1 (human): T278‑p, SF3B1 (mouse): T278‑p, SF3B1 (rat): T278‑p, SF3B1 (cow): T278‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T303-p - SF3B1 (human)
Modsite: tPKtERDtPGHGsGW SwissProt Entrez-Gene
Orthologous residues
SF3B1 (human): T303‑p, SF3B1 (mouse): T303‑p, SF3B1 (rat): T303‑p, SF3B1 (cow): T303‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T313-p - SF3B1 (human)
Modsite: HGsGWAEtPRtDrGG SwissProt Entrez-Gene
Orthologous residues
SF3B1 (human): T313‑p, SF3B1 (mouse): T313‑p, SF3B1 (rat): T313‑p, SF3B1 (cow): T313‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1130-p - SIPA1L1 (human)
Modsite: ERRLsPGsDIyVtVS SwissProt Entrez-Gene
Orthologous residues
SIPA1L1 (human): S1130‑p, SIPA1L1 iso2 (human): S1130‑p, SIPA1L1 (mouse): S1130‑p, SIPA1L1 (rat): S1169‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S338-p - SIRT6 (human)
Modsite: PKRERPtsPAPHRPP SwissProt Entrez-Gene
Orthologous residues
SIRT6 (human): S338‑p, SIRT6 iso2 (human): S311‑p, SIRT6 (mouse): S317‑p, SIRT6 (rat): S313‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T78-p - STX7 (human)
Modsite: kEFGsLPttPsEQRQ SwissProt Entrez-Gene
Orthologous residues
STX7 (human): T78‑p, STX7 iso2 (human): T78‑p, STX7 (mouse): T78‑p, STX7 (rat): T78‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S391-p - SUV39H1 (human)
Modsite: GLAGLPGsPKKRVRI SwissProt Entrez-Gene
Orthologous residues
SUV39H1 (human): S391‑p, SUV39H1 (mouse): S391‑p, SUV39H1 (rat): S392‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S386-p - TCF12 (human)
Modsite: PGGQAPssPsYENsL SwissProt Entrez-Gene
Orthologous residues
TCF12 (human): S386‑p, TCF12 iso2 (human): S216‑p, TCF12 iso3 (human): S386‑p, TCF12 iso4 (human): S150‑p, TCF12 (mouse): S386‑p, TCF12 iso2 (mouse): S386‑p, TCF12 (rat): S387‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S559-p - TCF20 (human)
Modsite: ASEKAGssPAQGAQN SwissProt Entrez-Gene
Orthologous residues
TCF20 (human): S559‑p, TCF20 iso2 (human): S559‑p, TCF20 (mouse): S588‑p, TCF20 (rat): S592‑p, TCF20 (cow): S568‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S203-p - TERF2IP (human)
Modsite: LLGDAPVsPssQkLK SwissProt Entrez-Gene
Orthologous residues
TERF2IP (human): S203‑p, TERF2IP (mouse): S200‑p, TERF2IP (rat): S200‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

Y23400-p - Titin (human)
Modsite: GGSKITGyIVEKKEL SwissProt Entrez-Gene
Orthologous residues
Titin (human): Y23400‑p, Titin iso3 (human): Y15976‑p, Titin iso6 (human): , Titin iso12 (human): Y25041‑p, Titin (mouse): Y24262‑p, Titin iso3 (mouse): , Titin iso4 (mouse): Y22516‑p, Titin (rat): Y23313‑p, Titin iso2 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

Y24482-p - Titin (human)
Modsite: GGSMITGyIVEKRDL SwissProt Entrez-Gene
Orthologous residues
Titin (human): Y24482‑p, Titin iso3 (human): Y17058‑p, Titin iso6 (human): , Titin iso12 (human): Y26123‑p, Titin (mouse): Y25344‑p, Titin iso3 (mouse): , Titin iso4 (mouse): Y23598‑p, Titin (rat): Y24332‑p, Titin iso2 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

Y25564-p - Titin (human)
Modsite: GGsKITGyIVEKKDL SwissProt Entrez-Gene
Orthologous residues
Titin (human): Y25564‑p, Titin iso3 (human): Y18140‑p, Titin iso6 (human): , Titin iso12 (human): Y27205‑p, Titin (mouse): Y26426‑p, Titin iso3 (mouse): , Titin iso4 (mouse): Y24680‑p, Titin (rat): Y25414‑p, Titin iso2 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T440-p - TMEM201 (human)
Modsite: LFRSPRRtsPssLPG SwissProt Entrez-Gene
Orthologous residues
TMEM201 (human): T440‑p, TMEM201 (mouse): V440‑p, TMEM201 (rat): V440‑p, TMEM201 (cow): A443‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S199-p - UBXN1 (human)
Modsite: PEPGPVPssPsQEPP SwissProt Entrez-Gene
Orthologous residues
UBXN1 (human): S199‑p, UBXN1 iso2 (human): S199‑p, UBXN1 (mouse): S199‑p, UBXN1 (rat): S199‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S952-p - USP36 (human)
Modsite: DPEAMEEsPRKKKKR SwissProt Entrez-Gene
Orthologous residues
USP36 (human): S952‑p, USP36 iso2 (human): S952‑p, USP36 (mouse): L931‑p, USP36 (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T46-p - VGLL4 (human)
Modsite: SALSSHRtGPPPIsP SwissProt Entrez-Gene
Orthologous residues
VGLL4 (human): T46‑p, VGLL4 iso2 (human): T15‑p, VGLL4 iso4 (human): T52‑p, VGLL4 (mouse): T52‑p, VGLL4 (rat): T52‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S52-p - VGLL4 (human)
Modsite: RtGPPPIsPsKRKFs SwissProt Entrez-Gene
Orthologous residues
VGLL4 (human): S52‑p, VGLL4 iso2 (human): S21‑p, VGLL4 iso4 (human): S58‑p, VGLL4 (mouse): S58‑p, VGLL4 (rat): S58‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S1210-p - WDR33 (human)
Modsite: HPPHDGHsPAsRERs SwissProt Entrez-Gene
Orthologous residues
WDR33 (human): S1210‑p, WDR33 iso2 (human): , WDR33 (mouse): S1204‑p, WDR33 (rat): S1205‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

T212-p - WIRE (human)
Modsite: REKPLPPtPGQRLHP SwissProt Entrez-Gene
Orthologous residues
WIRE (human): T212‑p, WIRE iso2 (human): T62‑p, WIRE (mouse): T212‑p, WIRE (rat): T212‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2

S620-p - ZC3H14 (human)
Modsite: CAYHHPIsPCkAFPN SwissProt Entrez-Gene
Orthologous residues
ZC3H14 (human): S620‑p, ZC3H14 iso2 (human): S620‑p, ZC3H14 iso3 (human): S464‑p, ZC3H14 iso4 (human): S455‑p, ZC3H14 iso5 (human): S595‑p, ZC3H14 iso6 (human): S191‑p, ZC3H14 iso9 (human): S615‑p, ZC3H14 (mouse): S620‑p, ZC3H14 (rat): S620‑p, ZC3H14 (cow): S620‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  gastric cancer
Relevant cell lines - cell types - tissues:  MKN-45 (gastric)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  1hr 1uM crizotinib, 24hr 1uM crizotinib, 3hr 1uM crizotinib, 6hr 1uM crizotinib, control1, control2