Hatton N, et al. (2015) Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor. Mol Cell Biol 35, 3131-44 26124282

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y980-p - JAK3 (human) ▲

Modsite: LLPLDkDyyVVREPG SwissProt Entrez-Gene Orthologous residues JAK3 (human): Y980‑p, JAK3 (mouse): Y976‑p, JAK3 iso2 (mouse): Y1195‑p, JAK3 iso3 (mouse): Y1189‑p, JAK3 (rat): Y976‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  MTLn3 (breast cell) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes EGF increase EGF PLD2 (human) augment treatment-induced increase

Y981-p - JAK3 (human) ▲

Modsite: LPLDkDyyVVREPGQ SwissProt Entrez-Gene Orthologous residues JAK3 (human): Y981‑p, JAK3 (mouse): Y977‑p, JAK3 iso2 (mouse): Y1196‑p, JAK3 iso3 (mouse): Y1190‑p, JAK3 (rat): Y977‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  MTLn3 (breast cell) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes EGF increase EGF PLD2 (human) augment treatment-induced increase

Y415-p - PLD2 (human) ▲

Modsite: ALGINSGysKRALML SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y415‑p, PLD2 (mouse): Y415‑p, PLD2 (rat): Y415‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  MTLn3 (breast cell) Cellular systems studied:  cell lines Species studied:  rat Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays JAK2 (human) Induces phosphorylation microscopy-colocalization