Curated Information
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Home > Curated Information Page > PubMed Id: 26063728
Nimlamool W, Andrews RM, Falk MM (2015) Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol Cell 26, 2755-68 26063728
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S255-p - GJA1 (pig)
Modsite: HATTGPLsPSKDCGs SwissProt
Orthologous residues
GJA1 (human): S255‑p, GJA1 (mouse): S255‑p, GJA1 (rat): S255‑p, GJA1 (rabbit): S255‑p, GJA1 (pig): S255‑p, GJA1 (hamster): N255‑p, GJA1 (cow): S256‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  PPAEC (endothelial)
Cellular systems studied:  primary cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
PD98059 VEGF inhibit treatment-induced increase
VEGF increase
GF109203X VEGF inhibit treatment-induced increase

S262-p - GJA1 (pig)
Modsite: sPSKDCGsPKYAYFN SwissProt
Orthologous residues
GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  PPAEC (endothelial)
Cellular systems studied:  primary cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
PD98059 VEGF inhibit treatment-induced increase

S279-p - GJA1 (pig)
Modsite: SSPTAPLsPMsPPGY SwissProt
Orthologous residues
GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  PPAEC (endothelial)
Cellular systems studied:  primary cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
PD98059 VEGF inhibit treatment-induced increase
VEGF increase
GF109203X VEGF inhibit treatment-induced increase

S282-p - GJA1 (pig)
Modsite: TAPLsPMsPPGYKLV SwissProt
Orthologous residues
GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  PPAEC (endothelial)
Cellular systems studied:  primary cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
PD98059 VEGF inhibit treatment-induced increase
VEGF increase
GF109203X VEGF inhibit treatment-induced increase

S368-p - GJA1 (pig)
Modsite: QRPSSRAsSRASSRP SwissProt
Orthologous residues
GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  PPAEC (endothelial)
Cellular systems studied:  primary cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
PD98059 VEGF no effect upon treatment-induced increase
GF109203X VEGF inhibit treatment-induced increase