Curated Information
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Home > Curated Information Page > PubMed Id: 26048985
Itoh Y, et al. (2015) Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes. J Biol Chem 290, 17879-93 26048985
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T221-p - QSK (human)
Modsite: TPGQLLKtWCGSPPY SwissProt Entrez-Gene
Orthologous residues
QSK (human): T221‑p, QSK iso6 (human): , QSK iso7 (human): T221‑p, QSK iso8 (human): T221‑p, QSK (mouse): T163‑p, QSK (rat): T221‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), AML12 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
pterosin_B no change compared to control

T469-p - QSK (human)
Modsite: YLSMRRHtVGVADPR SwissProt Entrez-Gene
Orthologous residues
QSK (human): T469‑p, QSK iso6 (human): , QSK iso7 (human): T469‑p, QSK iso8 (human): T421‑p, QSK (mouse): T411‑p, QSK (rat): T469‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), AML12 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PHKG2 (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
pterosin_B increase
miRNA decrease miRNA for mouse PHKG2

S551-p - QSK (human)
Modsite: GPLGRRAsDGGANIQ SwissProt Entrez-Gene
Orthologous residues
QSK (human): S551‑p, QSK iso6 (human): , QSK iso7 (human): S551‑p, QSK iso8 (human): S503‑p, QSK (mouse): S493‑p, QSK (rat): S551‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), AML12 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PHKG2 (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
pterosin_B increase
miRNA decrease miRNA for mouse PHKG2

T172-p - AMPKA2 (mouse)
Modsite: sDGEFLRtsCGsPNY SwissProt Entrez-Gene
Orthologous residues
AMPKA2 (human): T172‑p, AMPKA2 (mouse): T172‑p, AMPKA2 (rat): T172‑p, AMPKA2 (pig): T172‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), AML12 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
pterosin_B increase
colforsin decrease
HG9-91-01 no change compared to control

S133-p - CREB (mouse)
Modsite: EILsRRPsYRkILND SwissProt Entrez-Gene
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), AML12 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
pterosin_B decrease
colforsin increase
HG9-91-01 decrease