Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.8
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 25394490
Credle JJ, et al. (2015) GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein. Cell Death Differ 22, 838-51 25394490
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S129-p - SNCA (human)
Modsite: NEAyEMPsEEGyQDy SwissProt Entrez-Gene
Orthologous residues
SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Comments:  GSK-3B phosphorylation rate accelerated by dual influence of SNCA and Tau
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) microscopy-colocalization, transfection of constitutively active enzyme

T497-p - Tau (mouse)
Modsite: ssPGsPGtPGsRsRt SwissProt Entrez-Gene
Orthologous residues
Tau (human): T522‑p, Tau iso2 (human): T147‑p, Tau iso3 (human): T111‑p, Tau iso4 (human): T176‑p, Tau iso5 (human): T205‑p, Tau iso6 (human): T147‑p, Tau iso7 (human): T176‑p, Tau iso8 (human): T205‑p, Tau (mouse): T497‑p, Tau iso3 (mouse): T194‑p, Tau iso7 (mouse): T154‑p, Tau (rat): T516‑p, Tau (cow): T212‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

T504-p - Tau (mouse)
Modsite: tPGsRsRtPsLPtPP SwissProt Entrez-Gene
Orthologous residues
Tau (human): T529‑p, Tau iso2 (human): T154‑p, Tau iso3 (human): T118‑p, Tau iso4 (human): T183‑p, Tau iso5 (human): T212‑p, Tau iso6 (human): T154‑p, Tau iso7 (human): T183‑p, Tau iso8 (human): T212‑p, Tau (mouse): T504‑p, Tau iso3 (mouse): T201‑p, Tau iso7 (mouse): T161‑p, Tau (rat): T523‑p, Tau (cow): T219‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S527-p - Tau (mouse)
Modsite: VVRtPPKsPsAsKSR SwissProt Entrez-Gene
Orthologous residues
Tau (human): S552‑p, Tau iso2 (human): S177‑p, Tau iso3 (human): S141‑p, Tau iso4 (human): S206‑p, Tau iso5 (human): S235‑p, Tau iso6 (human): S177‑p, Tau iso7 (human): S206‑p, Tau iso8 (human): S235‑p, Tau (mouse): S527‑p, Tau iso3 (mouse): S224‑p, Tau iso7 (mouse): S184‑p, Tau (rat): S546‑p, Tau (cow): S242‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S554-p - Tau (mouse)
Modsite: NVRSkIGstENLKHQ SwissProt Entrez-Gene
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso4 (human): S233‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S648-p - Tau (mouse)
Modsite: RVQSKIGsLDnITHV SwissProt Entrez-Gene
Orthologous residues
Tau (human): S673‑p, Tau iso2 (human): S267‑p, Tau iso3 (human): S231‑p, Tau iso4 (human): S296‑p, Tau iso5 (human): S325‑p, Tau iso6 (human): S298‑p, Tau iso7 (human): S327‑p, Tau iso8 (human): S356‑p, Tau (mouse): S648‑p, Tau iso3 (mouse): S345‑p, Tau iso7 (mouse): S305‑p, Tau (rat): S667‑p, Tau (cow): S363‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S688-p - Tau (mouse)
Modsite: GAEIVyKsPVVsGDt SwissProt Entrez-Gene
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso4 (human): S336‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S696-p - Tau (mouse)
Modsite: PVVsGDtsPRHLsNV SwissProt Entrez-Gene
Orthologous residues
Tau (human): S721‑p, Tau iso2 (human): S315‑p, Tau iso3 (human): S279‑p, Tau iso4 (human): S344‑p, Tau iso5 (human): S373‑p, Tau iso6 (human): S346‑p, Tau iso7 (human): S375‑p, Tau iso8 (human): S404‑p, Tau (mouse): S696‑p, Tau iso3 (mouse): S393‑p, Tau iso7 (mouse): S353‑p, Tau (rat): S715‑p, Tau (cow): S411‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S701-p - Tau (mouse)
Modsite: DtsPRHLsNVsstGs SwissProt Entrez-Gene
Orthologous residues
Tau (human): S726‑p, Tau iso2 (human): S320‑p, Tau iso3 (human): S284‑p, Tau iso4 (human): S349‑p, Tau iso5 (human): S378‑p, Tau iso6 (human): S351‑p, Tau iso7 (human): S380‑p, Tau iso8 (human): S409‑p, Tau (mouse): S701‑p, Tau iso3 (mouse): S398‑p, Tau iso7 (mouse): S358‑p, Tau (rat): S720‑p, Tau (cow): S416‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model

S714-p - Tau (mouse)
Modsite: GsIDMVDsPQLATLA SwissProt Entrez-Gene
Orthologous residues
Tau (human): S739‑p, Tau iso2 (human): S333‑p, Tau iso3 (human): S297‑p, Tau iso4 (human): S362‑p, Tau iso5 (human): S391‑p, Tau iso6 (human): S364‑p, Tau iso7 (human): S393‑p, Tau iso8 (human): S422‑p, Tau (mouse): S714‑p, Tau iso3 (mouse): S411‑p, Tau iso7 (mouse): S371‑p, Tau (rat): S733‑p, Tau (cow): S429‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  mouse
Associated Diseases
Diseases Alterations Comments
Parkinson's disease increased In midbrain, significant hyperphosphorylation in PD mouse model