Park C, Kalinec F (2015) PKCα-Mediated Signals Regulate the Motile Responses of Cochlear Outer Hair Cells. Biophys J 108, 2171-80 25954875

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T445-p - ADD1 (human) ▲

Modsite: QkQQREKtRWLNSGR SwissProt Entrez-Gene Orthologous residues ADD1 (human): T445‑p, ADD1 iso2 (human): T445‑p, ADD1 iso3 (human): T445‑p, ADD1 iso4 (human): T445‑p, ADD1 iso6 (human): T445‑p, ADD1 (mouse): T445‑p, ADD1 iso2 (mouse): T445‑p, ADD1 iso3 (mouse): T445‑p, ADD1 (rat): T445‑p, ADD1 (cow): T445‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  outer hair cells (OHC) Cellular systems studied:  primary cells Species studied:  guinea pig Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPA increase bisindolylmaleimide LPA no change compared to control phorbol_ester increase bisindolylmaleimide phorbol_ester no effect upon treatment-induced increase

S726-p - ADD1 (human) ▲

Modsite: KKKFRtPsFLKKsKK SwissProt Entrez-Gene Orthologous residues ADD1 (human): S726‑p, ADD1 iso2 (human): ‑, ADD1 iso3 (human): S757‑p, ADD1 iso4 (human): ‑, ADD1 iso6 (human): ‑, ADD1 (mouse): S724‑p, ADD1 iso2 (mouse): ‑, ADD1 iso3 (mouse): ‑, ADD1 (rat): S724‑p, ADD1 (cow): S758‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  outer hair cells (OHC) Cellular systems studied:  primary cells Species studied:  guinea pig Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPA increase bisindolylmaleimide LPA inhibit treatment-induced increase C3_toxin LPA inhibit treatment-induced increase Y27632 LPA inhibit treatment-induced increase phorbol_ester increase bisindolylmaleimide phorbol_ester inhibit treatment-induced increase

S3-p - Cofilin-1 (human) ▲

Modsite: _____MAsGVAVsDG SwissProt Entrez-Gene Orthologous residues Cofilin‑1 (human): S3‑p, Cofilin‑1 (mouse): S3‑p, Cofilin‑1 (rat): S3‑p, Cofilin‑1 (pig): S3‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  outer hair cells (OHC) Cellular systems studied:  primary cells Species studied:  guinea pig Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes phorbol_ester decrease LPA increase bisindolylmaleimide LPA inhibit treatment-induced increase