Curated Information
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Home > Curated Information Page > PubMed Id: 25944903
Mei Z, et al. (2015) FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity. J Biol Chem 290, 16202-14 25944903
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T58-p - Myc (human)
Modsite: kkFELLPtPPLsPsR SwissProt Entrez-Gene
Orthologous residues
Myc (human): T58‑p, Myc iso2 (human): T73‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  Phosphorylation of T58 and S62 is required for c-Myc degradation mediated by FBW7, turnover of c-Myc by FBXO32 not dependent on these phosphorylation sites

S62-p - Myc (human)
Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene
Orthologous residues
Myc (human): S62‑p, Myc iso2 (human): S77‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  Phosphorylation of T58 and S62 is required for c-Myc degradation mediated by FBW7, turnover of c-Myc by FBXO32 not dependent on these phosphorylation sites

S71-p - Myc (human)
Modsite: sRRsGLCsPSyVAVt SwissProt Entrez-Gene
Orthologous residues
Myc (human): S71‑p, Myc iso2 (human): S86‑p, Myc (mouse): S71‑p, Myc (rat): S71‑p

Y74-p - Myc (human)
Modsite: sGLCsPSyVAVtPFs SwissProt Entrez-Gene
Orthologous residues
Myc (human): Y74‑p, Myc iso2 (human): Y89‑p, Myc (mouse): Y74‑p, Myc (rat): Y74‑p

K326-ub - Myc (human)
Modsite: YPAAkRVkLDsVRVL SwissProt Entrez-Gene
Orthologous residues
Myc (human): K326‑ub, Myc iso2 (human): K341‑ub, Myc (mouse): K326‑ub, Myc (rat): K326‑ub
Downstream Regulation
Effect of modification (function):  protein degradation, ubiquitination
Comments:  degradation induced by FBXO32

T358-p - Myc (human)
Modsite: EENVkRRtHNVLERQ SwissProt Entrez-Gene
Orthologous residues
Myc (human): T358‑p, Myc iso2 (human): T373‑p, Myc (mouse): T358‑p, Myc (rat): T358‑p

S373-p - Myc (human)
Modsite: RRNELkRsFFALRDQ SwissProt Entrez-Gene
Orthologous residues
Myc (human): S373‑p, Myc iso2 (human): S388‑p, Myc (mouse): S373‑p, Myc (rat): S373‑p