Donninger H, et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208, 777-89 25778922

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S46-p - p53 (human) ▲

Modsite: AMDDLMLsPDDIEQW SwissProt Entrez-Gene Orthologous residues p53 (human): S46‑p, p53 iso2 (human): S46‑p, p53 iso4 (human): S7‑p, p53 (mouse): ‑, p53 iso2 (mouse): ‑, p53 (rat): ‑, p53 (rabbit): S45‑p, p53 (green monkey): S46‑p Characterization Methods used to characterize site in vivo:  modification-specific antibody, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes RASSF5 (human) decrease RASSF5 (human) decrease HIPK2 RASSF5 mutant HRas (human) decrease

K382-ac - p53 (human) ▲

Modsite: QstsRHkkLMFktEG SwissProt Entrez-Gene Orthologous residues p53 (human): K382‑ac, p53 iso2 (human): ‑, p53 iso4 (human): K343‑ac, p53 (mouse): K379‑ac, p53 iso2 (mouse): ‑, p53 (rat): K380‑ac, p53 (rabbit): K380‑ac, p53 (green monkey): K382‑ac Characterization Methods used to characterize site in vivo:  modification-specific antibody, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes RASSF5 (human) increase RASSF5 (human) no change compared to control HIPK2 NORE1A R34A mutant