Curated Information
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Home > Curated Information Page > PubMed Id: 9295322
Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997) Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. J Biol Chem 272, 23769-74 9295322
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S341-p - SSTR3 (rat)
Modsite: RRILLRPsRRVRsQE SwissProt Entrez-Gene
Orthologous residues
SSTR3 (human): S332‑p, SSTR3 (mouse): S341‑p, SSTR3 (rat): S341‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S346-p - SSTR3 (rat)
Modsite: RPsRRVRsQEPGsGP SwissProt Entrez-Gene
Orthologous residues
SSTR3 (human): S337‑p, SSTR3 (mouse): S346‑p, SSTR3 (rat): S346‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S351-p - SSTR3 (rat)
Modsite: VRsQEPGsGPPEKtE SwissProt Entrez-Gene
Orthologous residues
SSTR3 (human): V342‑p, SSTR3 (mouse): S351‑p, SSTR3 (rat): S351‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T357-p - SSTR3 (rat)
Modsite: GsGPPEKtEEEEDEE SwissProt Entrez-Gene
Orthologous residues
SSTR3 (human): T348‑p, SSTR3 (mouse): T357‑p, SSTR3 (rat): T357‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
Effect of modification (function):  receptor internalization, altered