Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 25922519
Kawaai K, et al. (2015) IRBIT regulates CaMKII╬▒ activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proc Natl Acad Sci U S A 112, 5515-20 25922519
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S68-p - AHCYL1 (human)
Modsite: RSLSRSIsQSstdsY SwissProt Entrez-Gene
Orthologous residues
AHCYL1 (human): S68‑p, AHCYL1 (mouse): S68‑p, AHCYL1 (rat): S21‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial), MEF (fibroblast), SF9
Cellular systems studied:  cell lines
Species studied:  bacteria, mouse

S71-p - AHCYL1 (human)
Modsite: SRSIsQSstdsYSsA SwissProt Entrez-Gene
Orthologous residues
AHCYL1 (human): S71‑p, AHCYL1 (mouse): S71‑p, AHCYL1 (rat): S24‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial), MEF (fibroblast), SF9
Cellular systems studied:  cell lines
Species studied:  bacteria, mouse

S74-p - AHCYL1 (human)
Modsite: IsQSstdsYSsAASY SwissProt Entrez-Gene
Orthologous residues
AHCYL1 (human): S74‑p, AHCYL1 (mouse): S74‑p, AHCYL1 (rat): S27‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial), MEF (fibroblast), SF9
Cellular systems studied:  cell lines
Species studied:  bacteria, mouse

S77-p - AHCYL1 (human)
Modsite: SstdsYSsAASYTds SwissProt Entrez-Gene
Orthologous residues
AHCYL1 (human): S77‑p, AHCYL1 (mouse): S77‑p, AHCYL1 (rat): S30‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial), MEF (fibroblast), SF9
Cellular systems studied:  cell lines
Species studied:  bacteria, mouse

T286-p - CAMK2A (human)
Modsite: SCMHRQEtVDCLKKF SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T286‑p, CAMK2A iso2 (human): T286‑p, CAMK2A (mouse): T286‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T286‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial), MEF (fibroblast), SF9
Cellular systems studied:  cell lines
Species studied:  bacteria, mouse

S120-p - HOMER3 (human)
Modsite: ARLAREKsQDGGELT SwissProt Entrez-Gene
Orthologous residues
HOMER3 (human): S120‑p, HOMER3 iso2 (human): S120‑p, HOMER3 iso5 (human): , HOMER3 (mouse): S120‑p, HOMER3 iso2 (mouse): S120‑p, HOMER3 (rat): S120‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AHCYL1 (human) decrease

S19-p - TH (mouse)
Modsite: KGFRRAVsEQDtKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, ventral tegmental'-brain
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AHCYL1 (human) decrease AHCYL1 KO increase