Zhang X, Li L, McNaughton PA (2008) Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron 59, 450-61 18701070

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S117-p - TRPV1 (human) ▲
Modsite: LRLYDRRsIFEAVAQ SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S117‑p, TRPV1 (mouse): S117‑p, TRPV1 (rat): S116‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human

S502-p - TRPV1 (human) ▲

Modsite: YFLQRRPsMKTLFVD SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S502‑p, TRPV1 (mouse): S503‑p, TRPV1 (rat): S502‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (human) pharmacological inhibitor of upstream enzyme KINASE PKCA (human) pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase bradykinin increase PGE2 increase H-89 decrease AKAP5 (human) increase Downstream Regulation Effect of modification (function):  intracellular localization, receptor desensitization, altered

S801-p - TRPV1 (human) ▲

Modsite: VPLLREAsARDRQsA SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S801‑p, TRPV1 (mouse): S801‑p, TRPV1 (rat): S800‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCA (human) pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase bradykinin increase PGE2 increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered