Curated Information
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Home > Curated Information Page > PubMed Id: 25675510
Baldwin KT, Carbajal KS, Segal BM, Giger RJ (2015) Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A 112, 2581-6 25675510
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S133-p - CREB (mouse)
Modsite: EILsRRPsYRkILND SwissProt Entrez-Gene
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan increase
dectin-1 (mouse) no change compared to control dectin 1-/- no change
CARD9 (mouse) no change compared to control card9 -/- no change

T203-p - ERK1 (mouse)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan increase
dectin-1 (mouse) no change compared to control dectin-1-/-
CARD9 (mouse) increase CARD9 -/- increase

Y205-p - ERK1 (mouse)
Modsite: HtGFLtEyVAtRWyR SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan increase
dectin-1 (mouse) no change compared to control dectin-1-/-
CARD9 (mouse) increase CARD9 -/- increase

T183-p - ERK2 (mouse)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan increase
dectin-1 (mouse) no change compared to control dectin-1-/-
CARD9 (mouse) increase CARD9 -/- increase

Y185-p - ERK2 (mouse)
Modsite: HtGFLtEyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan increase
dectin-1 (mouse) no change compared to control dectin-1-/-
CARD9 (mouse) increase CARD9 -/- increase

S534-p - NFkB-p65 (mouse)
Modsite: sGDEDFssIADMDFS SwissProt Entrez-Gene
Orthologous residues
NFkB‑p65 (human): S536‑p, NFkB‑p65 (mouse): S534‑p, NFkB‑p65 (rat): S535‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan no change compared to control
dectin-1 (mouse) no change compared to control dectin-1 -/- no change
CARD9 (mouse) no change compared to control CARD9 -/- no change

Y519-p - Syk (mouse)
Modsite: ALRADENyyKAQTHG SwissProt Entrez-Gene
Orthologous residues
Syk (human): Y525‑p, Syk iso2 (human): Y502‑p, Syk (mouse): Y519‑p, Syk (rat): Y519‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan no change compared to control
curdlan dectin-1 (mouse) no change compared to control dectin-1 siRNA no change
CARD9 (mouse) no change compared to control CARD9 -/- no change

Y520-p - Syk (mouse)
Modsite: LRADENyyKAQTHGK SwissProt Entrez-Gene
Orthologous residues
Syk (human): Y526‑p, Syk iso2 (human): Y503‑p, Syk (mouse): Y520‑p, Syk (rat): Y520‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  mouse eye extracts
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
curdlan no change compared to control
curdlan dectin-1 (mouse) no change compared to control dectin-1 siRNA no change
CARD9 (mouse) no change compared to control CARD9 -/- no change