Curated Information
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Home > Curated Information Page > PubMed Id: 25801023
Ofengeim D, et al. (2015) Activation of necroptosis in multiple sclerosis. Cell Rep 10, 1836-49 25801023
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T357-p - MLKL (human)
Modsite: FELRkTQtsMSLGTt SwissProt Entrez-Gene
Orthologous residues
MLKL (human): T357‑p, MLKL (mouse): N344‑p, MLKL (rat): T344‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Associated Diseases
Diseases Alterations Comments
multiple sclerosis increased MS brain samples

S14-p - RIPK1 (human)
Modsite: LNVIKMkssDFLEsA SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S14‑p, RIPK1 iso2 (human): S14‑p, RIPK1 (mouse): S14‑p, RIPK1 (rat): S14‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Associated Diseases
Diseases Alterations Comments
multiple sclerosis increased MS brain samples

S15-p - RIPK1 (human)
Modsite: NVIKMkssDFLEsAE SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S15‑p, RIPK1 iso2 (human): S15‑p, RIPK1 (mouse): S15‑p, RIPK1 (rat): D15‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Associated Diseases
Diseases Alterations Comments
multiple sclerosis increased MS brain samples

S166-p - RIPK1 (human)
Modsite: LAsFkMWskLNNEEH SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S166‑p, RIPK1 iso2 (human): S120‑p, RIPK1 (mouse): S166‑p, RIPK1 (rat): S166‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Associated Diseases
Diseases Alterations Comments
multiple sclerosis increased MS brain samples

S227-p - RIPK3 (human)
Modsite: VELPtEPsLVYEAVC SwissProt Entrez-Gene
Orthologous residues
RIPK3 (human): S227‑p, RIPK3 (mouse): S232‑p, RIPK3 (rat): S229‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Associated Diseases
Diseases Alterations Comments
multiple sclerosis increased MS brain samples

S14-p - RIPK1 (mouse)
Modsite: LDNIKMAssDLLEKT SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S14‑p, RIPK1 iso2 (human): S14‑p, RIPK1 (mouse): S14‑p, RIPK1 (rat): S14‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cuprizone increase
7N-1 cuprizone inhibit treatment-induced increase

S15-p - RIPK1 (mouse)
Modsite: DNIKMAssDLLEKTD SwissProt Entrez-Gene
Orthologous residues
RIPK1 (human): S15‑p, RIPK1 iso2 (human): S15‑p, RIPK1 (mouse): S15‑p, RIPK1 (rat): D15‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cuprizone increase
7N-1 cuprizone inhibit treatment-induced increase