Curated Information
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Home > Curated Information Page > PubMed Id: 25594179
Yang J, et al. (2015) Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell 160, 161-76 25594179
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T308-p - Akt1 (mouse)
Modsite: KDGAtMKtFCGtPEy SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T308‑p, Akt1 iso2 (human): T246‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
axatomy increase sensory axon axatomy
MK-2206 decrease
ipatasertib increase

S473-p - Akt1 (mouse)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
axatomy increase sensory axon axatomy

T183-p - JNK1 (mouse)
Modsite: AGtsFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase S78A

Y185-p - JNK1 (mouse)
Modsite: tsFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase S78A

T183-p - JNK2 (mouse)
Modsite: ACTNFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK2 (human): T183‑p, JNK2 iso2 (human): T183‑p, JNK2 iso3 (human): T183‑p, JNK2 (mouse): T183‑p, JNK2 (rat): T183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nerve_damage increase
increase S78A

Y185-p - JNK2 (mouse)
Modsite: TNFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK2 (human): Y185‑p, JNK2 iso2 (human): Y185‑p, JNK2 iso3 (human): Y185‑p, JNK2 (mouse): Y185‑p, JNK2 (rat): Y185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nerve_damage increase
increase S78A

S78-p - MKK4 (mouse)
Modsite: IERLRTHsIESsGKL SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): S80‑p, MKK4 iso2 (human): S91‑p, MKK4 (mouse): S78‑p, MKK4 (rat): S78‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
axatomy increase sensory axon axatomy
MK-2206 decrease
ipatasertib decrease

S255-p - MKK4 (mouse)
Modsite: ISGQLVDsIAKtRDA SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): S257‑p, MKK4 iso2 (human): S268‑p, MKK4 (mouse): S255‑p, MKK4 (rat): S255‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nerve_damage increase
axatomy increase sensory axon axatomy
MK-2206 increase
ipatasertib decrease
SARM1 (mouse) increase SARM1 -/- inhibits
NMNAT1 (mouse) increase cytoNMNAT1 inhibits

T259-p - MKK4 (mouse)
Modsite: LVDsIAKtRDAGCRP SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): T261‑p, MKK4 iso2 (human): T272‑p, MKK4 (mouse): T259‑p, MKK4 (rat): T259‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nerve_damage increase
axatomy increase sensory axon axatomy
MK-2206 increase
ipatasertib decrease
SARM1 (mouse) increase SARM1 -/- inhibits
NMNAT1 (mouse) increase cytoNMNAT1 inhibits