Xue J, et al. (2015) Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat Commun 6, 6156 25639486

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S33-p - CTNNB1 (human) ▲
Modsite: QQQsyLDsGIHsGAT SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p, CTNNB1 (rabbit): S33‑p

S37-p - CTNNB1 (human) ▲
Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p, CTNNB1 (rabbit): S37‑p

T41-p - CTNNB1 (human) ▲
Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p, CTNNB1 (rabbit): T41‑p

S715-p - CTNNB1 (human) ▲

Modsite: GYRQDDPsyRsFHsG SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S715‑p, CTNNB1 (mouse): S715‑p, CTNNB1 (rat): S715‑p, CTNNB1 (rabbit): S715‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  brain cancer, glioblastoma, glioma Relevant cell lines - cell types - tissues:  U87MG (glial) Cellular systems studied:  cell lines, tissue Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCD (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCD (human) co-immunoprecipitation, transfection of inactive enzyme, transfection of constitutively active enzyme, siRNA inhibition of enzyme Downstream Regulation Effect of modification (function):  molecular association, regulation, protein degradation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TIF1G (human) Induces co-immunoprecipitation Comments:  TIF1G abolishes tumorigenesis