Curated Information
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Home > Curated Information Page > PubMed Id: 25719244
Jiang L, et al. (2015) Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells. Cell Death Dis 6, e1660 25719244
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S473-p - Akt1 (human)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GSK690693 decrease
MK-2206 decrease cytoplasmic fraction

T108-p - PHB (human)
Modsite: sQLPRIFtsIGEDyD SwissProt Entrez-Gene
Orthologous residues
PHB (human): T108‑p, PHB (mouse): T108‑p, PHB (rat): T108‑p, PHB (pig): T108‑p

S151-p - PHB (human)
Modsite: ELVSRQVsDDLTERA SwissProt Entrez-Gene
Orthologous residues
PHB (human): S151‑p, PHB (mouse): S151‑p, PHB (rat): S151‑p, PHB (pig): S151‑p

T258-p - PHB (human)
Modsite: LSRSRNItyLPAGQs SwissProt Entrez-Gene
Orthologous residues
PHB (human): T258‑p, PHB (mouse): T258‑p, PHB (rat): T258‑p, PHB (pig): T258‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation, modification site within consensus motif
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Effect of modification (process):  cell growth, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ER-alpha (human) Disrupts co-immunoprecipitation
Comments:  mitochondrial localization