Curated Information
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Home > Curated Information Page > PubMed Id: 25622187
Sundar R, Gudey SK, Heldin CH, Landström M (2015) TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor. Cell Cycle 14, 554-65 25622187
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K178-ub - TGFBR1 (human)
Modsite: IsEGTtLkDLIyDMt SwissProt Entrez-Gene
Orthologous residues
TGFBR1 (human): K178‑ub, TGFBR1 iso2 (human): K182‑ub, TGFBR1 (mouse): K178‑ub, TGFBR1 (rat): K176‑ub
Characterization
Methods used to characterize site in vivo immunoassay, mutation of modification site
Disease tissue studied:  prostate cancer
Relevant cell lines - cell types - tissues:  PC3 (prostate cell)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE TRAF6 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
UBIQUITIN LIGASE TRAF6 (human) siRNA inhibition of enzyme, co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  carcinogenesis, induced, cell cycle regulation, transcription, induced
Comments:  tumor cell invasion by inducing genes TßRI, Snail1, and matrix metallopeptidase 2 (MMP2)