Benavides-Serrato A, et al. (2014) mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma. Genes Cancer 5, 393-406 25568665

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S224-p - DUSP10 (human) ▲

Modsite: SCREGKDsFKRIFsK SwissProt Entrez-Gene Orthologous residues DUSP10 (human): S224‑p, DUSP10 (mouse): S225‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  brain cancer, glioblastoma, glioma Relevant cell lines - cell types - tissues:  U87MG (glial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE mTOR (human) Downstream Regulation Effect of modification (process):  apoptosis, induced, cell growth, inhibited

S230-p - DUSP10 (human) ▲

Modsite: DsFKRIFsKEIIVyD SwissProt Entrez-Gene Orthologous residues DUSP10 (human): S230‑p, DUSP10 (mouse): S231‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  brain cancer, glioblastoma, glioma Relevant cell lines - cell types - tissues:  U87MG (glial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE mTOR (human) Downstream Regulation Effect of modification (process):  apoptosis, induced, cell growth, inhibited