Guiton M, et al. (1995) Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. J Biol Chem 270, 20384-90 7657612

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y515-p - TrkB (rat) ▲

Modsite: PVIENPQyFGITNSQ SwissProt Entrez-Gene Orthologous residues TrkB (human): Y516‑p, TrkB iso2 (human): ‑, TrkB iso4 (human): Y532‑p, TrkB (mouse): Y515‑p, TrkB iso2 (mouse): ‑, TrkB (rat): Y515‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey

Y816-p - TrkB (rat) ▲

Modsite: LAkAsPVyLDILG__ SwissProt Entrez-Gene Orthologous residues TrkB (human): Y817‑p, TrkB iso2 (human): ‑, TrkB iso4 (human): Y833‑p, TrkB (mouse): Y816‑p, TrkB iso2 (mouse): ‑, TrkB (rat): Y816‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey

Y516-p - TrkC (rat) ▲

Modsite: PVIENPQyFRQGHNC SwissProt Entrez-Gene Orthologous residues TrkC (human): Y516‑p, TrkC iso2 (human): Y516‑p, TrkC (mouse): Y516‑p, TrkC (rat): Y516‑p, TrkC iso2 (rat): Y516‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, peptide sequencing, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes neurotrophin-3 increase Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SHC1 (mouse) Induces activity, induced co-immunoprecipitation, electrophoretic visualization PLCG1 (mouse) Induces activity, induced co-immunoprecipitation, electrophoretic visualization

Y859-p - TrkC (rat) ▲

Modsite: LGKATPIyLDILG__ SwissProt Entrez-Gene Orthologous residues TrkC (human): Y834‑p, TrkC iso2 (human): ‑, TrkC (mouse): Y820‑p, TrkC (rat): Y859‑p, TrkC iso2 (rat): ‑ Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, peptide sequencing, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes neurotrophin-3 increase Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SHC1 (mouse) Induces activity, induced co-immunoprecipitation, electrophoretic visualization PLCG1 (mouse) Induces activity, induced co-immunoprecipitation, electrophoretic visualization