Curated Information
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Home > Curated Information Page > PubMed Id: 29212172
Wang C, et al. (2017) Safflor yellow B reduces hypoxia-mediated vasoconstriction by regulating endothelial micro ribonucleic acid/nitric oxide synthase signaling. Oncotarget 8, 93551-93566 29212172
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1176-p - eNOS (rat)
Modsite: TSRIRtQsFsLQERQ SwissProt Entrez-Gene
Orthologous residues
eNOS (human): S1177‑p, eNOS (mouse): S1176‑p, eNOS (rat): S1176‑p, eNOS (rabbit): S1183‑p, eNOS (pig): S1179‑p, eNOS (cow): S1179‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  RAEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
deoxygenation decrease
Safflor yellow B increase
antimiR-199a decrease
L-NAME decrease

Y148-p - iNOS (rat)
Modsite: IEFINQYyGSFKEAK SwissProt Entrez-Gene
Orthologous residues
iNOS (human): Y151‑p, iNOS (mouse): Y145‑p, iNOS (rat): Y148‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  RAEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Safflor yellow B increase
deoxygenation increase
Safflor yellow B increase
antimiR-199a increase
L-NAME increase