Curated Information
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Home > Curated Information Page > PubMed Id: 15082798
Miyata Y, Nishida E (2004) CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol 24, 4065-74 15082798
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S13-p - CDC37 (rat)
Modsite: VWDHIEVsDDEDETH SwissProt Entrez-Gene
Orthologous residues
CDC37 (human): S13‑p, CDC37 (mouse): S13‑p, CDC37 (rat): S13‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (rat)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (rat) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TBB decrease
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAK (human) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation
MOK (human) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation
AurB (rat) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation
ICK (human) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation
RAF1 (rat) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation
Akt1 (rat) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation
CDK4 (human) Induces cell cycle regulation, cell growth, altered co-immunoprecipitation