Curated Information
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Home > Curated Information Page > PubMed Id: 14990569
Ouchi M, et al. (2004) BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem 279, 19643-8 14990569
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S308-p - BRCA1 (human)
Modsite: KAEFCNKskQPGLAR SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S308‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S308‑p, BRCA1 (mouse): S305‑p, BRCA1 (rat): S306‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell) [AurA (human)]
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AurA (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AurA (human) inhibition of upstream enzyme, transfection of wild-type enzyme