Curated Information
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Home > Curated Information Page > PubMed Id: 2479827
Fantl WJ, Escobedo JA, Williams LT (1989) Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis. Mol Cell Biol 9, 4473-8 2479827
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y856-p - PDGFRB (mouse)
Modsite: DIMRDSNyISkGSTF SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y857‑p, PDGFRB (mouse): Y856‑p, PDGFRB (rat): Y856‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection]
Cellular systems studied:  cell lines
Species studied:  hamster
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PDGFRB (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase