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Home > Curated Information Page > PubMed Id: 25501501
Beltran-Alvarez P, et al. (2015) Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel. Amino Acids 47, 429-34 25501501
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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R513-m1 - SCN5A (human)
Modsite: MNHLsLTrGLsRTsM SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): R513‑m1, SCN5A (mouse): H513‑m1, SCN5A (rat): H514‑m1
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro)
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (human)

R513-m2 - SCN5A (human)
Modsite: MNHLsLTrGLsRTsM SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): R513‑m2, SCN5A (mouse): H513‑m2, SCN5A (rat): H514‑m2
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro)
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (human)

S516-p - SCN5A (human)
Modsite: LsLTrGLsRTsMKPR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S516‑p, SCN5A (mouse): S516‑p, SCN5A (rat): S517‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro)
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
Effect of modification (function):  methylation
Comments:  inhibits SCN5A methylation at R513

S524-p - SCN5A (human)
Modsite: RTsMKPRssrGsIFt SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S524‑p, SCN5A (mouse): S524‑p, SCN5A (rat): S525‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro)
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

S525-p - SCN5A (human)
Modsite: TsMKPRssrGsIFtF SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): S525‑p, SCN5A (mouse): S525‑p, SCN5A (rat): S526‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro)
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

R526-m1 - SCN5A (human)
Modsite: sMKPRssrGsIFtFR SwissProt Entrez-Gene
Orthologous residues
SCN5A (human): R526‑m1, SCN5A (mouse): R526‑m1, SCN5A (rat): R527‑m1
Characterization
Methods used to characterize site in vivo mass spectrometry, mass spectrometry (in vitro)
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  bacteria, human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE PRMT3 (human)