Curated Information
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Home > Curated Information Page > PubMed Id: 25402275
Oelze M, et al. (2014) The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity. PLoS One 9, e112394 25402275
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y656-p - eNOS (rat)
Modsite: FGLGSRAyPHFCAFA SwissProt Entrez-Gene
Orthologous residues
eNOS (human): Y657‑p, eNOS (mouse): Y656‑p, eNOS (rat): Y656‑p, eNOS (rabbit): Y663‑p, eNOS (pig): Y659‑p, eNOS (cow): Y659‑p

S1176-p - eNOS (rat)
Modsite: TSRIRtQsFsLQERQ SwissProt Entrez-Gene
Orthologous residues
eNOS (human): S1177‑p, eNOS (mouse): S1176‑p, eNOS (rat): S1176‑p, eNOS (rabbit): S1183‑p, eNOS (pig): S1179‑p, eNOS (cow): S1179‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  aorta
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
streptozotocin decrease
Downstream Regulation
Effect of modification (function):  activity, induced

S236-p - VASP (rat)
Modsite: GAKLRKVsKEEASGG SwissProt Entrez-Gene
Orthologous residues
VASP (human): S239‑p, VASP (mouse): S235‑p, VASP (rat): S236‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
streptozotocin decrease