Luo HB, et al. (2014) SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A 111, 16586-91 25378699

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S198-p - Tau iso8 (human) ▲

Modsite: sGDRsGyssPGsPGt SwissProt Entrez-Gene Orthologous residues Tau (human): S515‑p, Tau iso2 (human): S140‑p, Tau iso3 (human): S104‑p, Tau iso4 (human): S169‑p, Tau iso5 (human): S198‑p, Tau iso6 (human): S140‑p, Tau iso7 (human): S169‑p, Tau iso8 (human): S198‑p, Tau (mouse): S490‑p, Tau iso3 (mouse): S187‑p, Tau iso7 (mouse): S147‑p, Tau (rat): S509‑p, Tau (cow): S205‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Relevant cell lines - cell types - tissues:  'brain, cerebral cortex', neuron-'brain, hippocampus' Cellular systems studied:  primary cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes beta-amyloid_40 increase

S199-p - Tau iso8 (human) ▲

Modsite: GDRsGyssPGsPGtP SwissProt Entrez-Gene Orthologous residues Tau (human): S516‑p, Tau iso2 (human): S141‑p, Tau iso3 (human): S105‑p, Tau iso4 (human): S170‑p, Tau iso5 (human): S199‑p, Tau iso6 (human): S141‑p, Tau iso7 (human): S170‑p, Tau iso8 (human): S199‑p, Tau (mouse): S491‑p, Tau iso3 (mouse): S188‑p, Tau iso7 (mouse): S148‑p, Tau (rat): S510‑p, Tau (cow): S206‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Relevant cell lines - cell types - tissues:  'brain, cerebral cortex', neuron-'brain, hippocampus' Cellular systems studied:  primary cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes beta-amyloid_40 increase

S202-p - Tau iso8 (human) ▲

Modsite: sGyssPGsPGtPGsR SwissProt Entrez-Gene Orthologous residues Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso4 (human): S173‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Relevant cell lines - cell types - tissues:  'brain, cerebral cortex', neuron-'brain, hippocampus' Cellular systems studied:  primary cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes beta-amyloid_40 increase

T205-p - Tau iso8 (human) ▲

Modsite: ssPGsPGtPGsRsRt SwissProt Entrez-Gene Orthologous residues Tau (human): T522‑p, Tau iso2 (human): T147‑p, Tau iso3 (human): T111‑p, Tau iso4 (human): T176‑p, Tau iso5 (human): T205‑p, Tau iso6 (human): T147‑p, Tau iso7 (human): T176‑p, Tau iso8 (human): T205‑p, Tau (mouse): T497‑p, Tau iso3 (mouse): T194‑p, Tau iso7 (mouse): T154‑p, Tau (rat): T516‑p, Tau (cow): T212‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, cerebral cortex', 293 (epithelial) Cellular systems studied:  cell lines, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ginkgolic acid decrease beta-amyloid_40 increase

S214-p - Tau iso8 (human) ▲

Modsite: GsRsRtPsLPtPPtR SwissProt Entrez-Gene Orthologous residues Tau (human): S531‑p, Tau iso2 (human): S156‑p, Tau iso3 (human): S120‑p, Tau iso4 (human): S185‑p, Tau iso5 (human): S214‑p, Tau iso6 (human): S156‑p, Tau iso7 (human): S185‑p, Tau iso8 (human): S214‑p, Tau (mouse): S506‑p, Tau iso3 (mouse): S203‑p, Tau iso7 (mouse): S163‑p, Tau (rat): S525‑p, Tau (cow): S221‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human

T231-p - Tau iso8 (human) ▲

Modsite: KKVAVVRtPPKsPss SwissProt Entrez-Gene Orthologous residues Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso4 (human): T202‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human

S262-p - Tau iso8 (human) ▲

Modsite: NVKskIGstENLkHQ SwissProt Entrez-Gene Orthologous residues Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso4 (human): S233‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ginkgolic acid decrease

K340-sm - Tau iso8 (human) ▲

Modsite: GGGQVEVksEkLDFK SwissProt Entrez-Gene Orthologous residues Tau (human): K657‑sm, Tau iso2 (human): K251‑sm, Tau iso3 (human): K215‑sm, Tau iso4 (human): K280‑sm, Tau iso5 (human): K309‑sm, Tau iso6 (human): K282‑sm, Tau iso7 (human): K311‑sm, Tau iso8 (human): K340‑sm, Tau (mouse): K632‑sm, Tau iso3 (mouse): K329‑sm, Tau iso7 (mouse): K289‑sm, Tau (rat): K651‑sm, Tau (cow): K347‑sm Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, modification-specific antibody, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes okadaic_acid increase beta-amyloid_40 increase Downstream Regulation Effect of modification (function):  phosphorylation, protein stabilization, ubiquitination Comments:  induces phosphorylation of itself at multiple sites and inhibits its ubiquitination

S396-p - Tau iso8 (human) ▲

Modsite: GAEIVyKsPVVsGDt SwissProt Entrez-Gene Orthologous residues Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso4 (human): S336‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ginkgolic acid decrease

S404-p - Tau iso8 (human) ▲

Modsite: PVVsGDtsPRHLsNV SwissProt Entrez-Gene Orthologous residues Tau (human): S721‑p, Tau iso2 (human): S315‑p, Tau iso3 (human): S279‑p, Tau iso4 (human): S344‑p, Tau iso5 (human): S373‑p, Tau iso6 (human): S346‑p, Tau iso7 (human): S375‑p, Tau iso8 (human): S404‑p, Tau (mouse): S696‑p, Tau iso3 (mouse): S393‑p, Tau iso7 (mouse): S353‑p, Tau (rat): S715‑p, Tau (cow): S411‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human