Zou Y, et al. (2004) Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem 279, 27790-8 15075324

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T286-p - CCND1 (mouse) ▲

Modsite: EEAGLACtPTDVRDV SwissProt Entrez-Gene Orthologous residues CCND1 (human): T286‑p, CCND1 (mouse): T286‑p, CCND1 (rat): T286‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  Mv1Lu (pulmonary) Cellular systems studied:  cell lines Species studied:  mink Enzymes shown to modify site in vitro:  Type Enzyme KINASE GSK3B (mouse) KINASE DYRK1B (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE DYRK1B (mouse) transfection of constitutively active enzyme, transfection of wild-type enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes lithium decrease

T288-p - CCND1 (mouse) ▲

Modsite: AGLACTPtDVRDVDI SwissProt Entrez-Gene Orthologous residues CCND1 (human): T288‑p, CCND1 (mouse): T288‑p, CCND1 (rat): T288‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  Mv1Lu (pulmonary) Cellular systems studied:  cell lines Species studied:  mink Enzymes shown to modify site in vitro:  Type Enzyme KINASE GSK3B (mouse) KINASE DYRK1B (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE DYRK1B (mouse) transfection of constitutively active enzyme, transfection of wild-type enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes lithium decrease Downstream Regulation Effect of modification (function):  protein degradation