Curated Information
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Home > Curated Information Page > PubMed Id: 25265012
Wang X, et al. (2014) Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression. PLoS One 9, e104723 25265012
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S7-p - TTK (human)
Modsite: _MEsEDLsGRELtID SwissProt Entrez-Gene
Orthologous residues
TTK (human): S7‑p, TTK iso2 (human): S7‑p, TTK (mouse): I7‑p, TTK iso2 (mouse): I7‑p, TTK (rat): I7‑p, TTK (frog): S7‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

T12-p - TTK (human)
Modsite: DLsGRELtIDsIMNk SwissProt Entrez-Gene
Orthologous residues
TTK (human): T12‑p, TTK iso2 (human): T12‑p, TTK (mouse): T12‑p, TTK iso2 (mouse): T12‑p, TTK (rat): T12‑p, TTK (frog): K12‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

S15-p - TTK (human)
Modsite: GRELtIDsIMNkVRD SwissProt Entrez-Gene
Orthologous residues
TTK (human): S15‑p, TTK iso2 (human): S15‑p, TTK (mouse): S15‑p, TTK iso2 (mouse): S15‑p, TTK (rat): S15‑p, TTK (frog): S15‑p

T33-p - TTK (human)
Modsite: kFkNEDLtDELsLNK SwissProt Entrez-Gene
Orthologous residues
TTK (human): T33‑p, TTK iso2 (human): T33‑p, TTK (mouse): T32‑p, TTK iso2 (mouse): T32‑p, TTK (rat): T32‑p, TTK (frog): T34‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

S37-p - TTK (human)
Modsite: EDLtDELsLNKISAD SwissProt Entrez-Gene
Orthologous residues
TTK (human): S37‑p, TTK iso2 (human): S37‑p, TTK (mouse): S36‑p, TTK iso2 (mouse): S36‑p, TTK (rat): N36‑p, TTK (frog): T38‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

S321-p - TTK (human)
Modsite: SkPsGNDsCELRNLk SwissProt Entrez-Gene
Orthologous residues
TTK (human): S321‑p, TTK iso2 (human): S321‑p, TTK (mouse): S342‑p, TTK iso2 (mouse): S316‑p, TTK (rat): S317‑p, TTK (frog): S349‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

T360-p - TTK (human)
Modsite: sITLKNktEssLLAk SwissProt Entrez-Gene
Orthologous residues
TTK (human): T360‑p, TTK iso2 (human): T360‑p, TTK (mouse): T380‑p, TTK iso2 (mouse): T354‑p, TTK (rat): T355‑p, TTK (frog): Q388‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

S363-p - TTK (human)
Modsite: LKNktEssLLAkLEE SwissProt Entrez-Gene
Orthologous residues
TTK (human): S363‑p, TTK iso2 (human): S363‑p, TTK (mouse): S383‑p, TTK iso2 (mouse): S357‑p, TTK (rat): S358‑p, TTK (frog): S391‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

T371-p - TTK (human)
Modsite: LLAkLEEtkEyQEPE SwissProt Entrez-Gene
Orthologous residues
TTK (human): T371‑p, TTK iso2 (human): T371‑p, TTK (mouse): T390‑p, TTK iso2 (mouse): T364‑p, TTK (rat): P365‑p, TTK (frog): P393‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TTK (human)
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell cycle regulation
Comments:  autophosphorylation of this site is required for release TTK from kinetochore;causes decreased kinetochore localization of BubR1 and Mad2.

T676-p - TTK (human)
Modsite: NQMQPDttsVVkDSQ SwissProt Entrez-Gene
Orthologous residues
TTK (human): T676‑p, TTK iso2 (human): T675‑p, TTK (mouse): T675‑p, TTK iso2 (mouse): T649‑p, TTK (rat): T654‑p, TTK (frog): T697‑p

T686-p - TTK (human)
Modsite: VkDSQVGtVNYMPPE SwissProt Entrez-Gene
Orthologous residues
TTK (human): T686‑p, TTK iso2 (human): T685‑p, TTK (mouse): T685‑p, TTK iso2 (mouse): T659‑p, TTK (rat): T664‑p, TTK (frog): T707‑p