Curated Information
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Home > Curated Information Page > PubMed Id: 25262337
Kang M, et al. (2014) Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling. Cell Commun Signal 12, 58 25262337
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S262-p - GJA1 (mouse)
Modsite: sPskDCGsPkyAyFN SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'heart, ventricle', myocyte-heart
Cellular systems studied:  primary cultured cells, tissue
Species studied:  mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
2-APB decrease
ATP increase
XeC increase

S368-p - GJA1 (mouse)
Modsite: QRPssRAssRAssRP SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'heart, ventricle', myocyte-heart
Cellular systems studied:  primary cultured cells, tissue
Species studied:  mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
2-APB decrease
ATP increase
XeC increase

S262-p - GJA1 (rat)
Modsite: sPskDCGsPkyAyFN SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'heart, ventricle', myocyte-heart
Cellular systems studied:  primary cultured cells, tissue
Species studied:  mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
2-APB decrease
IP3R1 (rat) increase shRNA decrease

S279-p - GJA1 (rat)
Modsite: SSPTAPLsPMsPPGY SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p
Characterization
Methods used to characterize site in vivo immunoassay, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'heart, ventricle', myocyte-heart
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IP3/BM increase
ATP increase
IP3R1 (rat) increase shRNA decrease
2-APB decrease
phorbol_ester increase

S282-p - GJA1 (rat)
Modsite: TAPLsPMsPPGYkLV SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p
Characterization
Methods used to characterize site in vivo immunoassay, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'heart, ventricle', myocyte-heart
Cellular systems studied:  cell lines, primary cultured cells, tissue
Species studied:  human, mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IP3/BM increase
ATP increase
IP3R1 (rat) increase shRNA decrease
2-APB decrease
phorbol_ester increase

S368-p - GJA1 (rat)
Modsite: QRPssRAssRAssRP SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'heart, ventricle', myocyte-heart
Cellular systems studied:  primary cultured cells, tissue
Species studied:  mouse, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase
2-APB decrease
IP3R1 (rat) increase IP3R1-shRNA decreases