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Home > Curated Information Page > PubMed Id: 25082828
Swiderski K, et al. (2014) Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting. Hum Mol Genet 23, 6697-711 25082828
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T1136-p - dystrophin (human)
Modsite: TELKELNtQWDHMCQ SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): T1136‑p, dystrophin iso5 (human): , dystrophin iso6 (human): , dystrophin (mouse): T1138‑p, dystrophin iso3 (mouse): , dystrophin iso6 (mouse): , dystrophin (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

T2656-p - dystrophin (human)
Modsite: RDysADDtRKVHMIT SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): T2656‑p, dystrophin iso5 (human): , dystrophin iso6 (human): , dystrophin (mouse): T2649‑p, dystrophin iso3 (mouse): , dystrophin iso6 (mouse): , dystrophin (rat):
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3066-p - dystrophin (human)
Modsite: GPWERAIsPNKVPYY SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3066‑p, dystrophin iso5 (human): , dystrophin iso6 (human): , dystrophin (mouse): S3059‑p, dystrophin iso3 (mouse): , dystrophin iso6 (mouse): S351‑p, dystrophin (rat):
Characterization
Methods used to characterize site in vivo immunoassay, immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein stabilization
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DAG1 (human) Induces co-immunoprecipitation

T3081-p - dystrophin (human)
Modsite: INHETQTtCWDHPKM SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): T3081‑p, dystrophin iso5 (human): T13‑p, dystrophin iso6 (human): T13‑p, dystrophin (mouse): T3074‑p, dystrophin iso3 (mouse): T13‑p, dystrophin iso6 (mouse): , dystrophin (rat): T13‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse

Y3359-p - dystrophin (human)
Modsite: MHyPMVEyCtPTTSG SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): Y3359‑p, dystrophin iso5 (human): Y291‑p, dystrophin iso6 (human): Y291‑p, dystrophin (mouse): Y3352‑p, dystrophin iso3 (mouse): Y291‑p, dystrophin iso6 (mouse): , dystrophin (rat): Y291‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse

T3361-p - dystrophin (human)
Modsite: yPMVEyCtPTTSGED SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): T3361‑p, dystrophin iso5 (human): T293‑p, dystrophin iso6 (human): T293‑p, dystrophin (mouse): T3354‑p, dystrophin iso3 (mouse): T293‑p, dystrophin iso6 (mouse): , dystrophin (rat): T293‑p
Characterization
Methods used to characterize site in vivo immunoassay, immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein stabilization
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DAG1 (human) Induces in vitro

S3424-p - dystrophin (human)
Modsite: PVDSAPAssPQLsHD SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3424‑p, dystrophin iso5 (human): S343‑p, dystrophin iso6 (human): S356‑p, dystrophin (mouse): S3417‑p, dystrophin iso3 (mouse): S343‑p, dystrophin iso6 (mouse): , dystrophin (rat): S343‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3425-p - dystrophin (human)
Modsite: VDSAPAssPQLsHDD SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3425‑p, dystrophin iso5 (human): S344‑p, dystrophin iso6 (human): S357‑p, dystrophin (mouse): S3418‑p, dystrophin iso3 (mouse): S344‑p, dystrophin iso6 (mouse): , dystrophin (rat): S344‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3429-p - dystrophin (human)
Modsite: PAssPQLsHDDTHSR SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3429‑p, dystrophin iso5 (human): S348‑p, dystrophin iso6 (human): S361‑p, dystrophin (mouse): S3422‑p, dystrophin iso3 (mouse): S348‑p, dystrophin iso6 (mouse): , dystrophin (rat): S348‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3483-p - dystrophin (human)
Modsite: CQSLNQDsPLSQPRs SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3483‑p, dystrophin iso5 (human): S402‑p, dystrophin iso6 (human): S415‑p, dystrophin (mouse): S3476‑p, dystrophin iso3 (mouse): S402‑p, dystrophin iso6 (mouse): , dystrophin (rat): S402‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3490-p - dystrophin (human)
Modsite: sPLSQPRsPAQILIS SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3490‑p, dystrophin iso5 (human): S409‑p, dystrophin iso6 (human): S422‑p, dystrophin (mouse): S3483‑p, dystrophin iso3 (mouse): S409‑p, dystrophin iso6 (mouse): , dystrophin (rat): S409‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse

T3548-p - dystrophin (human)
Modsite: sPPEMMPtsPQsPRD SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): T3548‑p, dystrophin iso5 (human): T467‑p, dystrophin iso6 (human): T480‑p, dystrophin (mouse): T3541‑p, dystrophin iso3 (mouse): T467‑p, dystrophin iso6 (mouse): , dystrophin (rat): T467‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3549-p - dystrophin (human)
Modsite: PPEMMPtsPQsPRDA SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3549‑p, dystrophin iso5 (human): S468‑p, dystrophin iso6 (human): S481‑p, dystrophin (mouse): S3542‑p, dystrophin iso3 (mouse): S468‑p, dystrophin iso6 (mouse): , dystrophin (rat): S468‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3552-p - dystrophin (human)
Modsite: MMPtsPQsPRDAELI SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3552‑p, dystrophin iso5 (human): S471‑p, dystrophin iso6 (human): S484‑p, dystrophin (mouse): S3545‑p, dystrophin iso3 (mouse): S471‑p, dystrophin iso6 (mouse): , dystrophin (rat): S471‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S3615-p - dystrophin (human)
Modsite: GTtVssPstsLQRsD SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3615‑p, dystrophin iso5 (human): S534‑p, dystrophin iso6 (human): S547‑p, dystrophin (mouse): S3608‑p, dystrophin iso3 (mouse): S534‑p, dystrophin iso6 (mouse): , dystrophin (rat): S534‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3621-p - dystrophin (human)
Modsite: PstsLQRsDssQPML SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3621‑p, dystrophin iso5 (human): S540‑p, dystrophin iso6 (human): S553‑p, dystrophin (mouse): S3614‑p, dystrophin iso3 (mouse): S540‑p, dystrophin iso6 (mouse): , dystrophin (rat): S540‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse

S3623-p - dystrophin (human)
Modsite: tsLQRsDssQPMLLR SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3623‑p, dystrophin iso5 (human): S542‑p, dystrophin iso6 (human): S555‑p, dystrophin (mouse): S3616‑p, dystrophin iso3 (mouse): S542‑p, dystrophin iso6 (mouse): , dystrophin (rat): S542‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S3624-p - dystrophin (human)
Modsite: sLQRsDssQPMLLRV SwissProt Entrez-Gene
Orthologous residues
dystrophin (human): S3624‑p, dystrophin iso5 (human): S543‑p, dystrophin iso6 (human): S556‑p, dystrophin (mouse): S3617‑p, dystrophin iso3 (mouse): S543‑p, dystrophin iso6 (mouse): , dystrophin (rat): S543‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
Cellular systems studied:  cell lines
Species studied:  mouse