Gradin K, Takasaki C, Fujii-Kuriyama Y, Sogawa K (2002) The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine. J Biol Chem 277, 23508-14 11983697

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T796-p - HIF1A (human) ▲
Modsite: ESGLPQLtSYDCEVN SwissProt Entrez-Gene Orthologous residues HIF1A (human): T796‑p, HIF1A (mouse): T806‑p, HIF1A (rat): T795‑p Downstream Regulation Effect of modification (process):  transcription, induced

S834-p - HIF2A (mouse) ▲

Modsite: ASRLLGPsFEPYLLP SwissProt Entrez-Gene Orthologous residues HIF2A (human): S830‑p, HIF2A (mouse): S834‑p, HIF2A (rat): S834‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, inhibited

T844-p - HIF2A (mouse) ▲

Modsite: PYLLPELtRyDCEVN SwissProt Entrez-Gene Orthologous residues HIF2A (human): T840‑p, HIF2A (mouse): T844‑p, HIF2A (rat): T844‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, induced

Y846-p - HIF2A (mouse) ▲
Modsite: LLPELtRyDCEVNVP SwissProt Entrez-Gene Orthologous residues HIF2A (human): Y842‑p, HIF2A (mouse): Y846‑p, HIF2A (rat): Y846‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

S857-p - HIF2A (mouse) ▲
Modsite: VNVPVPGsSTLLQGR SwissProt Entrez-Gene Orthologous residues HIF2A (human): S853‑p, HIF2A (mouse): S857‑p, HIF2A (rat): S857‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human