Curated Information
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Home > Curated Information Page > PubMed Id: 11927579
Zrachia A, et al. (2002) Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. J Biol Chem 277, 23693-701 11927579
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y52-p - PKCD (human)
Modsite: VQKKPtMyPEWKSTF SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y52‑p, PKCD iso2 (human): Y52‑p, PKCD (mouse): Y52‑p, PKCD iso2 (mouse): Y52‑p, PKCD (rat): Y52‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  C6 (glial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase SVNI virus
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  apoptosis, altered

Y64-p - PKCD (human)
Modsite: STFDAHIyEGRVIQI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y64‑p, PKCD iso2 (human): Y64‑p, PKCD (mouse): Y64‑p, PKCD iso2 (mouse): Y64‑p, PKCD (rat): Y64‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  C6 (glial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase SVNI virus
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  apoptosis, altered

Y187-p - PKCD (human)
Modsite: WGLNkQGyKCRQCNA SwissProt Entrez-Gene
Orthologous residues
PKCD (human): Y187‑p, PKCD iso2 (human): Y187‑p, PKCD (mouse): Y187‑p, PKCD iso2 (mouse): Y187‑p, PKCD (rat): Y187‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  C6 (glial)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
virus infection increase SVNI virus
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  apoptosis, altered