Kontos CD, Cha EH, York JD, Peters KG (2002) The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol 22, 1704-13 11865050

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y1113-p - TIE1 (mouse) ▲

Modsite: MLEARKAyVNMSLFE SwissProt Entrez-Gene Orthologous residues TIE1 (human): Y1117‑p, TIE1 (mouse): Y1113‑p, TIE1 (rat): Y1116‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE TIE1 (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE TIE1 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes M-CSF increase Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIK3R1 (mouse) SH2 Induces activity, induced co-immunoprecipitation, electrophoretic visualization

Y1100-p - TIE2 (mouse) ▲

Modsite: MLEERKTyVNTTLyE SwissProt Entrez-Gene Orthologous residues TIE2 (human): Y1102‑p, TIE2 (mouse): Y1100‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE TIE2 (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE TIE2 (mouse) transfection of wild-type enzyme, transfection of inactive enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes M-CSF increase Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIK3R1 (mouse) SH2 Induces activity, induced co-immunoprecipitation, electrophoretic visualization